feature which "today has no place in the pathology of coronary disease", while it dia not even mention the coronary vessels, which play "a decisive role" in the disease Leibowitz claims to have diagnosed. In his retrospective diagnosis, therefore, Leibowitz has to ignore evidence which is given, and invent evidence which is not given. Just how great a discordance is required between our medical...

OBJECTIVE To assess the potential relation between plaque composition and vascular remodelling by using spectral analysis of intravascular ultrasound (IVUS) radiofrequency data. METHODS AND RESULTS 41 coronary vessels with non-significant (< 50% diameter stenosis by angiography), < or = 20 mm, non-ostial lesions located in non-culprit vessels underwent IVUS interrogation. IVUS radiofrequency ...

feature which "today has no place in the pathology of coronary disease", while it dia not even mention the coronary vessels, which play "a decisive role" in the disease Leibowitz claims to have diagnosed. In his retrospective diagnosis, therefore, Leibowitz has to ignore evidence which is given, and invent evidence which is not given. Just how great a discordance is required between our medical...

Okajima, Masaki, Robert Parent, Eric Thorin, and Michel Lavallée. Pathophysiological plasma ET-1 levels antagonize -adrenergic dilation of coronary resistance vessels in conscious dogs. Am J Physiol Heart Circ Physiol 287: H1476–H1483, 2004. First published June 17, 2004; 10.1152/ajpheart.00297.2004.—On the basis of in vitro experiments showing that endothelin (ET)-1 interferes with smooth musc...

To compare angiographically-determined coronary artery disease in diabetic patients with controls, 1,653 patients coming to cardiac catheterization were reviewed retrospectively to find 37 diabetic and 79 control patients matched for sex, age (+/- 3 years), and risk factors (hypertension, hyperlipidemia, and smoking). The severity of coronary artery disease was assessed using an angiographic gr...

Previously, we showed that development of myocardial necrotic lesions is associated with impaired endothelium-dependent coronary artery relaxation in young cardiomyopathic hamsters. Since active necrosis declines with aging, this study was designed to determine whether coronary artery endothelium-dependent relaxation to ACh is restored and to identify the mechanisms mediating this effect. Intra...