BACKGROUND Whereas excess adiposity is presumed to be advantageous for the skeleton, studies investigating relations between bone strength and fat during youth have been equivocal. OBJECTIVES Relations of percentage body fat (BF) and bone strength indexes were assessed in late adolescent females, taking into consideration surrogates of muscle force [ie, muscle cross-sectional area (MCSA) and ...

Disuse typically causes an imbalance in bone formation and bone resorption, leading to losses of cortical and trabecular bone. In contrast, bears maintain balanced intracortical remodeling and prevent cortical bone loss during disuse (hibernation). Trabecular bone, however, is more detrimentally affected than cortical bone in other animal models of disuse. Here we investigated the effects of hi...

OBJECTIVES The degree of penetration of an antibiotic into the infected site is an important criterion for therapeutic success. Ertapenem is a new carbapenem, exhibiting activity against most Gram-positive and Gram-negative aerobic and anaerobic bacteria commonly recovered from community-acquired infections. However, no studies concerning its diffusion into bone and synovial tissue are availabl...

The overall mechanical behaviour of cortical bone is strongly dependant on its microstructure. X-ray computed tomography (XCT) has been widely used to identify the microstructural morphology tissue (i.e. pore network, Haversian and Volkmann's canals). However, connection between microstructure mechanics during plastic deformation unclear. Hence, purpose this study provide an in-depth evaluation...

This study aims to determine the anatomical structure and histochemical test of terpenoid phenol compounds in two varieties green betel plants (Piper betle). Making leaves preparations using fresh method, testing with 5% copper acetate, ferric trichloride 10% some grains sodium carbonate. The observations leaf 1 2 have similarities consisting upper epidermis, hypodermis, palisade parenchyma, pa...

Multiple biomimetic approaches have been attempted to accelerate the regeneration of functional bone tissue. While most synthetic scaffolds are designed to mimic the architecture of trabecular bone, in the current study, cortical bone-like extracellular matrix was regenerated in vitro within organized structures. Biphasic calcium phosphate (BCaP) and hydroxyapatite (HAp) scaffolds were develope...

INTRODUCTION A strong positive correlation between the apparent ultimate strength and stiffness of bone tissue has been observed for cortical bone in tension and low-density cancellous bone in compression [1]. For practical purposes, the existence of a relationship between strength and stiffness is significant in that bone strength can be predicted using non-invasive stiffness measurements. Fro...

BACKGROUND Bone density at the interradicular area plays an important role during orthodontic treatment. In view of this fact, the study was designed to quantitatively evaluate the bone density at the interradicular areas of the alveolar and basal bones of maxilla and mandible by computed tomography. METHODS One hundred and nine computed tomographic images were randomly selected, and bone den...

The bone-sparing effect of estrogens is mediated primarily via estrogen receptor (ER)α, which stimulates gene transcription through activation function (AF)-1 and AF-2. The role of ERαAF-1 for the estradiol (E2) effects is tissue specific. The selective ER modulators (SERMs) raloxifene (Ral), lasofoxifene (Las), and bazedoxifene (Bza) can be used to treat postmenopausal osteoporosis. They all r...

Tissue inhibitor of metalloproteinases-3 (TIMP-3) regulates extracellular matrix via its inhibition of matrix metalloproteinases and membrane-bound sheddases. Timp-3 is expressed at multiple sites of extensive tissue remodelling. This extends to bone where its role, however, remains largely unresolved. In this study, we have used Micro-CT to assess bone mass and architecture, histological and h...