In this paper, we describe the effectiveness of combination between an organic solvent system mixture with orthoformates different chain sizes from one to four carbon atoms. These orthoesters have been used as a “water trapper/alcohol releaser molecule” reach notable improvement in enantioselectivity and enantiomeric excess our target compound, (S)-2-(4-isobutylphenyl)propanoic acid (ibuprofen ...

Although it is widely known that trimethylamine N-oxide (TMAO), an osmolyte used by nature, stabilizes the folded state of proteins, the underlying mechanism of action is not entirely understood. To gain further insight into this important biological phenomenon, we use the C≡N stretching vibration of an unnatural amino acid, p-cyano-phenylalanine, to directly probe how TMAO affects the hydratio...

The Gibbs free energy of transferring a solute at infinite dilution between two solvents quantifies differences in solute-solvent interactions - if the transfer takes place at constant molarity of the solute. Yet, many calculation formulae and measuring instructions that are commonly used to quantify solute-solvent interactions correspond to transfer processes in which not the molarity of the s...

Previous studies using lipid extracts of heather (Calluna vulgaris) leaves showed the presence of high concentrations of ursolic and oleanolic acid. These two compounds have been reported to present antiviral activity against hepatitis C virus (HCV). In this work, the supercritical fluid extraction of heather was studied with the aim of assessing a potential anti-HCV activity of the extracts ow...

The current challenges of the pharmaceutical industry regarding environmental impact caused by its waste have led to design and development more efficient industrial processes. In this context, solubility studies are at core different processes, such as formulation, preformulation, synthesis, purification, recrystallization, quantification, quality control. This research evaluates sulfamerazine...