Journal:
:iranian journal of basic medical sciences
0
seyed adel moallem pharmaceutical research center, mashhad university of medical sciences, mashhad, iran
2 medical toxicology research center, mashhad university of medical sciences, mashhad, iran
3 department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran
mohsen imenshahidi department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran
narges shahini department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran
ahmad reza javan department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran
mohsen karimi department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran
mona alibolandi biotechnology research center, mashhad university of medical sciences, mashhad, iran
objective(s): nowadays, cox- 2 inhibitors such as valdecoxib are removed from the market because of their cardiovascular toxicity and their potential to increase the risk of strokes. in response to this, medicinal chemists have attempted to synthesize new classes of cox-2 inhibitors. materials and methods: in this study, three novel analogues of thiazolidin-4-ones derivatives 2a-c were synthe...
