نتایج جستجو برای: cox models
تعداد نتایج: 943575 فیلتر نتایج به سال:
The Cox regression model is a cornerstone of modern survival analysis and is widely used in many other fields as well. But the Cox models with time-change covariates are not easy to understand or visualize. We therefore offer a simple and easy-to-understand interpretation of the (arbitrary) baseline hazard and time-change covariate. This interpretation also provides a way to simulate variables ...
A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity. According to in-vitro COX-1/COX-2 inhibition data, all compounds (6a-g) were selective inhibitors of COX-2 isoenzyme with IC50 values in the highly potent 0.08-0.16 mM range. These results indicated that both potency and selectivity o...
In this paper, a global goodness-of-fit test statistic for a Cox regression model, which has an approximate chi-squared distribution when the model has been correctly specified, is proposed. Our goodness-of-fit statistic is global and has power to detect if interactions or higher order powers of covariates in the model are needed. The proposed statistic is similar to the Hosmer and Lemeshow (19...
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