In order to determine whether qualitative and quantitative differences exist between the non-collagenous proteins of crown and root dentin, rat incisors were separated into their enamel- and cementum-related dentin portions (ERD and CRD, respectively). Isolation of the mineral-bound proteins was performed under nondegradative conditions. Analytical procedures included DEAE-chromatography on hig...

This phase 1/2 study in patients with newly diagnosed multiple myeloma (N 53) assessed CRd—carfilzomib (20, 27, or 36 mg/m2, days 1, 2, 8, 9, 15, 16 and 1, 2, 15, 16 after cycle 8), lenalidomide (25 mg/d, days 1-21), and weekly dexamethasone (40/20 mg cycles 1-4/5 )— in 28-day cycles. After cycle 4, transplantation-eligible candidates underwent stem cell collection (SCC) then continued CRd with...

Establishing phylogenetic relationships within a clade can help to infer ancestral origins and indicate how widespread species reached their current biogeographic distributions. The small plovers, genus Charadrius, are cosmopolitan shorebirds, distributed across all continents except Antarctica. Here we present a global, species-level molecular phylogeny of this group based on four nuclear (ADH...

Clostridium difficile is a major nosocomial pathogen that produces two large protein toxins [toxin A (TcdA) and toxin B (TcdB)] capable of disrupting intestinal epithelial cells. Both belong to the family of large clostridial cytotoxins, which are characterized by the presence of a repetitive C-terminal repetitive domain (CRD). In TcdA, the CRD is composed of 39 repeats that are responsible for...

On a sample of 65 subjects rheoencephalography (REG)--the electrical impedance plethysmographic method for assessment of cerebral circulation was applied, as well as an electronic psychodiagnostic instrument Complex Reactionmeter Drenovac (CRD) constructed for assessment of complex psychomotor reactions. The aim of this study was to evaluate the potential differences between subjects with and w...

Background Allergy to peach and apple is a frequent problem in the Mediterranean area. Both fruits share allergens between them and with those from other plants and pollens. Component resolved diagnosis assays (CRD) enable to detect IgE antibodies to a wide panel of allergens. A detailed clinical evaluation plus CRD permit a precise analysis of sensitizations to many allergens. Our aim was to a...

Record Status This article is related to a Cochrane Protocol or Review which is published in the Cochrane Database of Systematic Reviews where it will be regularly updated. Cochrane Reviews are of a high standard and are not evaluated by CRD. The link is:http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001273.pub3/abstractThis article is related to a Cochrane Protocol or Review which is pu...

Cone–rod dystrophies (crd) represent a group of progressive inherited blinding diseases characterized by primary dysfunction and loss of cone photoreceptors accompanying or preceding rod death. Recessive crd type 1 was described in dogs associated with an RPGRIP1 exon 2 mutation, but with lack of complete concordance between genotype and phenotype. This review highlights role of the RPGRIP1, a ...