Doxorubicin (DOX) induces oxidative stress leading to cardiotoxicity. Diosgenin, a steroidal saponin of Dioscorea opposita, has been reported to have antioxidant activity. Our study was aimed to find out the protective effect of diosgenin against DOX-induced cardiotoxicity in mice. DOX treatment led to a significant decrease in the ratio of heart weight to body weight, and increases in the bloo...

objective: this study aimed to determine the association of cardiac risk factors and the risk of acute myocardial infarction (ami) in emergency department (ed) patients with non-diagnostic ecg changes. methods: this cross-sectional study was conducted in the ed of imam hossein hospital during a period of one year. in this study, patients with symptoms suggestive of ami including chest pain, dys...

where ATP = adenosine triphosphate and ADP= adenosine diphosphate. The substances most commonly determined have been creatine or creatine phosphate; e.g. Banga (1943), Askonas (1951), Narayanaswami (1952), Ennor & Rosenberg (1954), Kuby, Noda & Lardy (1954) and Chappell & Perry (1954). These methods may not always be convenient for the determination of creatine phosphokinase activity in tissue ...

To build upon recent findings that mitochondrial JNK signaling is inhibited by selectively blocking the interaction between JNK and Sab, we utilized a cell-permeable peptide to demonstrate that ischemia/reperfusion (I/R) injury could be protected in vivo and that JNK mitochondrial signaling was the mechanism by which reactive oxygen species (ROS) generation, mitochondrial dysfunction, and cardi...

Myxedematous psychosis was first described in 1979 by Pr Asher, it is a rare diagnosis associating an acute psychosis, rhabdomyolysis whose etiology hypothyroidism. We report the case of 32-year-old patient followed for 6 years schizophrenia, who had not any treatment 3 years, and admitted with psychotic attack consisting delusions persecution. The examination revealed oedematose syndrome, deep...

Background: Knowledge about Immune-Mediated Necrotizing Myopathy (IMNM) has received significantly attention in recent years. In this study, we report a rare case of IMNM with increased Creatine Phosphokinase (CPK) and positive Signal Recognition Particle (SRP). Clinical Presentation and Intervention: The case was a 67-year-old male patient referred to Firozgar hospital affiliated to the Iran ...

Еhe anabolic properties of a new composition leuzea and cranberry meal extracts in ratio 7:50, containing ecdisten ursolic acid, respectively, have been investigates on model isolated overload the skeletal muscle rats leg by method excision. Material methods. The experiment was conducted Wistar stock both sexes weighing 220–250 g. At beginning experiment, all animals underwent musculus gastrocn...

Objective: This study aimed to determine the association of cardiac risk factors and the risk of Acute Myocardial Infarction (AMI) in Emergency Department (ED) patients with non-diagnostic ECG changes. Methods: This cross-sectional study was conducted in the ED of Imam Hossein Hospital during a period of one year. In this study, patients with symptoms s...