The era of genomics brings the potential of better DNA-based risk prediction and treatment. We explore this problem for chronic lymphocytic leukaemia that is one of the largest whole exome data set available from the NIH dbGaP database. We perform a standard next-generation sequence procedure to obtain Single-Nucleotide Polymorphism (SNP) variants and obtain a peak mean accuracy of 82% in our c...

Used to estimate the risk of an estimator or to perform model selection, cross-validation is a widespread strategy because of its simplicity and its apparent universality. Many results exist on the model selection performances of cross-validation procedures. This survey intends to relate these results to the most recent advances of model selection theory, with a particular emphasis on distingui...

Cross-validation is a useful and generally applicable technique often employed in machine learning, including decision tree induction. An important disadvantage of straightforward implementation of the technique is its computational overhead. In this paper we show that, for decision trees, the computational overhead of cross-validation can be reduced signiicantly by integrating the cross-valida...

KeBABS provides a powerful, flexible and easy to use framework for KE: rnel- B: ased A: nalysis of B: iological S: equences in R. It includes efficient implementations of the most important sequence kernels, also including variants that allow for taking sequence annotations and positional information into account. KeBABS seamlessly integrates three common support vector machine (SVM) implementa...

to provide the validated and standardized form of the persian version of the ages and stages questionnaires as an appropriate developmental screening tool for evaluation of iranian children's development.this was a cross-sectional study. translation and back-translation, content validity determination, cultural and lingual modifications, pilot study on 100 parents and inter-rater reliability de...

abstract this study investigated the validity of processability theory proposed by pienemann (1998/2015) among iranian efl learners’ oral performance. the theory defines six procedural stages for learners in the process of second language acquisition. in order to conduct the study, 10 intermediate efl learners were selected based on their performance on oxford placement test. then, they partici...