We have developed crosslinked salmon-derived atelocollagen (SC) sponge, which has a denaturation temperature of 47°C. Sixty-four knees of 32 mature rabbits were randomly divided into 4 groups after creating an osteochondral defect in the femoral trochlea. Defects in Groups I, II, and III were filled with the crosslinked SC sponge, the crosslinked porcine collagen (PC) sponge, and the non-crossl...

Allyl amides were synthesised from the reaction of allyl alcohols and halogenated nitriles using a platinum multifaceted catalysis approach in which both the nucleophilic addition and subsequent [3,3]-sigmatropic rearrangement steps of the process were catalysed by the same complex. Additionally, (1)H/(13)C{(1)H} NMR and GC studies provided the first insights into the mechanism of this transfor...

Over the past decade, investigators in orthopaedic biomechanics at the Massachusetts General Hospital have contributed extensively to the development of the highly crosslinked ultra-high molecular weight polyethylenes (UHMWPEs). These highly crosslinked polyethylenes exhibit significant improvement in wear performance when compared with the conventional polyethylenes when studied in vitro in hi...

It is still a major challenge for targeted cancer chemotherapy to design stable biodegradable micellar drug delivery systems which show a rapid and complete intracellular drug release. Here, reversibly core-crosslinked pH-responsive biodegradable micelles were developed based on poly(ethylene glycol)-poly(2,4,6-trimethoxybenzylidene-pentaerythritol carbonate-co-pyridyl disulfide carbonate) [PEG...

Abstract We present an experimental and theoretical exploration of well‐dispersed, distinctively stable, fumed SiO 2 crosslinked polyethylene (XLPE) nanocomposites. The mechanical properties /XLPE nanocomposites were assessed with different concentrations , which had noticed that network morphology was immensely influential for the performance properties. A reasonable micromechanical models com...