نتایج جستجو برای: csf and 400 25 ml
تعداد نتایج: 16901051 فیلتر نتایج به سال:
1’TIIE FORMULA of an indicator strip test* for proteinuria, which utilizes the protein error of indicators, was modified in 1959. There have been few reports of experiences with the modified test. Because this strip test is designed to indicate only protein concentrations in excess of about 30 mg./100 ml., it might be thought that the test would readily differentiate a normal cerebrospinal flui...
Objective We describe the case of a patient with an extensive autoimmune response after one dose pembrolizumab, emphasizing importance early recognition diverse presentation complications from checkpoint inhibitors. Background A 55-year-old woman myxoid chondrosarcoma right hand, previously treated chemotherapy that received excellent tumor response. One month later she developed progressive me...
It has been suggested that central nervous system (CNS) neuroexcitation plays an important role in digitalis-induced cardiac arrhythmias. To elucidate further the role of the CNS in digitalis-induced arrhythmias, the inotropic and toxic effects of a highly polar semisynthetic cardiac glycoside, 3beta-O-(4 amino-4,6 dideoxy-beta-D-galactopyranosyl)-digitoxigenin (ASI-222) were compared to those ...
BACKGROUND Markers of human brain dopamine metabolism are reported to decline with age. However, the cerebrospinal fluid (CSF) concentration of homovanillic acid (HVA), a major dopamine metabolite, is reported to not change or to increase in elderly individuals. OBJECTIVE To estimate the rate of delivery of HVA from the brain to CSF, taking into account the HVA concentration gradient in the s...
BACKGROUND No definitive, antemortem diagnostic test for canine degenerative myelopathy (DM) is available. Phosphorylated neurofilament heavy (pNF-H) is a promising biomarker for nervous system diseases. HYPOTHESIS/OBJECTIVE Cerebrospinal fluid (CSF) and serum pNF-H is a detectable biological marker for diagnosis of canine DM. ANIMALS Fifty-three DM-affected, 27 neurologically normal, 7 asy...
PURPOSE Gemcitabine is an excellent candidate for regional therapy. We quantified cerebrospinal fluid (CSF) and plasma concentrations of gemcitabine and its inactive metabolite, 2',2'-difluorodeoxyuridine (dFdU), in nonhuman primates given intrathecal gemcitabine. EXPERIMENTAL DESIGN Three nonhuman primates received 5 mg of gemcitabine via lateral ventricle. CSF was sampled from the fourth ve...
1 N-Isopropyl-p-iodoamphetamine hydrochloride (IMP) is predominantly metabolized by CYP2C19
OBJECTIVE To evaluate cerebrospinal fluid (CSF) and serum neurofilament light chain (NfL) levels in genetic frontotemporal dementia (FTD) as a potential biomarker in the presymptomatic stage and during the conversion into the symptomatic stage. Additionally, to correlate NfL levels to clinical and neuroimaging parameters. METHODS In this multicenter case-control study, we investigated CSF NfL...
OBJECTIVE AND DESIGN Though combination antiretroviral therapy reduces the concentration of HIV-1 RNA in both plasma and cerebrospinal fluid (CSF) below the detection limit of clinical assays, low levels of HIV-1 RNA are frequently detectable in plasma using more sensitive assays. We examined the frequency and magnitude of persistent low-level HIV-1 RNA in CSF and its relation to the central ne...
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