نتایج جستجو برای: csf1
تعداد نتایج: 305 فیلتر نتایج به سال:
Abstract AIMS Glioblastoma (GBM) remains incurable because of the high level intratumor heterogeneity and poor understanding its complex genetics. We recently identified adenosine to inosine (A-to-I) RNA editing as a sex- specific prognostic factor in GBM. However, underlying mechanism unclear. sought identify editing-associated molecular effectors assess their prognosis potential. METHOD analy...
TREM-1 (triggering receptor expressed on myeloid cells-1) is an orphan immunoreceptor expressed on monocytes, macrophages, and neutrophils. TREM-1 associates with and signals via the adapter protein DAP12/TYROBP, which contains an ITAM. TREM-1 activation by receptor cross-linking has been shown to be proinflammatory and to amplify some cellular responses to TLR ligands such as bacterial LPS. To...
Glioma growth and progression are characterized by abundant development of blood vessels that are highly aberrant and poorly functional, with detrimental consequences for drug delivery efficacy. The mechanisms driving this vessel dysmorphia during tumor progression are poorly understood. Using longitudinal intravital imaging in a mouse glioma model, we identify that dynamic sprouting and functi...
Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte traffic throughout the body and may help regulate site-specific bone resorption. We investigated bone gene expression in vivo during rapid osteoclast differentiation induced by colonystimulating factor 1 (CSF-1) in Csf1-null toothless (tl/tl) rats. Long-bone RNA f...
Successful engineering of complex organs requires improved methods to promote rapid and stable vascularization of artificial tissue scaffolds. Toward this goal, tissue engineering strategies utilize the release of pro-angiogenic growth factors, alone or in combination, from biomaterials to induce angiogenesis. In this study we have used intravital microscopy to define key, dynamic cellular chan...
The Rockefeller University Press $30.00 J. Exp. Med. Vol. 206 No. 3 595-606 www.jem.org/cgi/doi/10.1084/jem.20081385 595 Monocytes, macrophages, and DCs form networks of phagocytic cells throughout most tissues, the development of which are dependent on the CSF-1 receptor (csf1r, also known as CD115, c-fms, and M-CSF receptor) ( 1, 2 ). These cells, which are sometimes referred to as the mononu...
The uncertainty evaluation of CSF2, the second caesium fountain primary frequency standard at PTB, is presented. The fountain uses optical molasses to cool atoms down to 0.6μK. The atoms are launched vertically in a moving optical molasses, and state-selected in the |F = 3,mF = 0〉 hyperfine ground state. During their ballistic flight, the atoms interact twice with a microwave field, thus comple...
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