purpose : churg-strauss syndrome (css) is a rare form of small vessel necrotizing vasculitis. retinal artery and vein occlusion are very rare findings in these patients and they are treated by high-dose corticosteroids and cytotoxics. we describe a rare case of css under high-dose corticosteroids and cytotoxic treatment, presenting central retinal artery occlusion (crao). case report : a 45-yea...

BACKGROUND The enriched biological activity information of compounds in large and freely-accessible chemical databases like the PubChem Bioassay Database has become a powerful research resource for the scientific research community. Currently, 2D fingerprint based conventional similarity search (CSS) is the most common widely used approach for database screening, but it does not typically incor...

CSS codes are in one-to-one correspondance with length 3 chain complexes. The latter are naturally endowed with a tensor product ⊗ which induces a similar operation on the former. We investigate this operation, and in particular its behavior with regard to minimum distances. Given a CSS code C, we give a criterion which provides a lower bound on the minimum distance of C ⊗ D for every CSS code ...

Psychosocial stress is a major factor driving gastrointestinal (GI) pathophysiology and disease susceptibility in humans and animals. The mechanisms governing susceptibility to stress-induced GI disease remain poorly understood. In the present study, we investigated the influence of chronic social stress (CSS) in pigs, induced by 7 d of chronic mixing/crowding stress, on intestinal barrier and ...

OBJECTIVE To investigate whether cortical superficial siderosis (cSS) on MRI, especially if disseminated (involving more than 3 sulci), increases the risk of future symptomatic lobar intracerebral hemorrhage (ICH) in cerebral amyloid angiopathy (CAA). METHODS European multicenter cohort study of 118 patients with CAA (104 with baseline symptomatic lobar ICH) diagnosed according to the Boston ...

The article presents three advanced citation-based methods used to detect potential breakthrough papers among very highly cited papers. We approach the detection of such papers from three different perspectives in order to provide different typologies of breakthrough papers. In all three cases we use the classification of scientific publications developed at CWTS based on direct citation relati...

The processor speeds continue to improve at a faster rate than the memory access times. The issue of data locality is still unsolved, and continues to be a problem given the widening gap between processor speeds and memory access times. Compiler research has chosen to address this problem in many directions including source code transformations of loops, static data reorganization, dynamic data...

the aetiology behind odor-related chronic somatic symptoms (o-rcss) is unknown, although both immunological and psychiatric causes have been suggested. the aim of this study was to investigate the occurrence of self-reported asthma and hay fever and psychiatric symptoms in individuals having o-rcss compared to individuals with similar chronic somatic symptoms (css) which were not odors-related,...