نتایج جستجو برای: ct26 tumor model

تعداد نتایج: 2480440  

Journal: :Bioelectrochemistry 2021

• In vitro , lipofection of CCL5/CCL17 modifies the expression cytokines. The main driver these changes was entry foreign DNA into cytosol. vivo ECT pulses lead to high Ccl5 and Ccl17 after GET. GET CCL5 or CCL17 results in increased Cxcl9 Ifn? . are potent activators immune system CT26 tumor model. effectiveness immunotherapy highly correlates with degree type infiltrated cells tissue. Treatme...

Journal: :Oncology reports 2014
Jing Kuang Ya-Lan Wang Ming Xiao Yi Tang Wen-Wen Chen Guang-Lin Song Xi Yang Ming Li

Arginine-specific ADP-ribosyltransferase 1 (ART1) and poly(ADP-ribose) polymerase-1 (PARP-1) are both post‑translational modification proteins. Inhibition of PARP1 induces apoptosis in cancer cells, and ART1 regulates RhoA which promotes apoptosis in hepatic cancer cells when inhibited. However, the interaction of ART1 and PARP-1 on the effect of apoptosis has not yet been elucidated. In the pr...

2017
Jinhua Zhu Meihui Liu Yuanfen Liu Yiting Zhang Bing Yang Wei Zhang

Zoledronic acid (ZOL) is the third generation of bisphosphonates, which can inhibit many tumors growth, especially to inhibit the growth of colon cancer. However, the molecular mechanism is still very mysterious. In this study, we observed that ZOL could regulate CT26 colon cancer cells autophagy, promote CT26 cells apoptosis, and inhibit CT26 cells proliferation. Western blotting analysis show...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2001
S A Holden Y Lan A M Pardo J S Wesolowski S D Gillies

PURPOSE Immune-based therapies, such as the immunocytokine huKS-IL2, exert potent antitumor responses in some animal models by targeting cytokine activity to the tumor microenvironment. We found that certain chemotherapy agents in the appropriate dose and schedule can augment the antitumor activity of huKS-IL2. EXPERIMENTAL DESIGN Chemotherapy agents were given in a single dose followed 1 day...

2010
Pawel Mroz Angelika Szokalska Mei X. Wu Michael R. Hamblin

BACKGROUND The mechanism by which the immune system can effectively recognize and destroy tumors is dependent on recognition of tumor antigens. The molecular identity of a number of these antigens has recently been identified and several immunotherapies have explored them as targets. Photodynamic therapy (PDT) is an anti-cancer modality that uses a non-toxic photosensitizer and visible light to...

2017
Ji-Ye Kee Yo-Han Han Jinbong Park Dae-Seung Kim Jeong-Geon Mun Kwang Seok Ahn Hyun-Jung Kim Jae-Young Um Seung-Heon Hong

BACKGROUND β-Lapachone is a quinone-containing compound found in red lapacho ( Tabebuia impetiginosa, syn. T avellanedae) trees. Lapacho has been used in traditional medicine by several South and Central American indigenous people to treat various types of cancer. The purpose of this study was to investigate the antimetastatic properties of β-lapachone and the underlying mechanisms using colon ...

Journal: :Cancer research 1984
E Pearlstein C Ambrogio S Karpatkin

Three different murine tumors, CT26 colon adenocarcinoma, Lewis lung carcinoma, and B16 amelanotic melanoma, were injected into syngeneic mice (BALB/c and C57BL/6J) to test the effect of rabbit anti-mouse platelet antibody on the development of pulmonary metastases. Antiplatelet antibody, when injected i.p., decreased the platelet count from 1.5 x 10(6)/microliters to 0.12 x 10(6)/microliters a...

Journal: :Cancer research 1996
R S Chamberlain M W Carroll V Bronte P Hwu S Warren J C Yang M Nishimura B Moss S A Rosenberg N P Restifo

Activation of T lymphocytes in the absence of a costimulatory signal can result in anergy or apoptotic cell death. Two molecules capable of providing a costimulatory signal, B7-1 (CD80) and B7-2 (CD86), have been shown to augment the immunogenicity of whole-tumor cell vaccines. To explore a potential role for costimulation in the design of recombinant anticancer vaccines, we used lacZ-transduce...

2014
N. Selcan Turker Pedram Heidari Raju Kucherlapati Melanie Kucherlapati Umar Mahmood

Colorectal cancer is a serious complication associated with inflammatory bowel disease, often indistinguishable by screening with conventional FDG PET probes. We have developed an alternative EGFR-targeted PET imaging probe that may be used to overcome this difficulty, and successfully assessed its utility for neoplastic lesion detection in preclinical models. Cetuximab F(ab')2 fragments were e...

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