The position of the acetabular cup is a major factor in the long-term outcome of total hip arthroplasty (THA). Malpositioning of the acetabular cup frequently has been reported with the use of a minimally invasive implantation technique. It remains unclear whether the limited visibility or the increased retractor traction and thus tilting of the pelvis during cup implantation is the cause. This...

BACKGROUND Although surgical navigation reduces the rate of malpositioned acetabular cups in total hip arthroplasty (THA), its use has not been widely adopted. As a result of our perceived need for simple and efficient methods of navigation, we developed a mechanical navigation device for acetabular cup orientation. QUESTIONS/PURPOSES We assessed accuracy of cup orientation (mean error of cup...

In this study, cup-shaped copper sheets were developed to improve heat dispassion for high-power light emitting diodes (LEDs) array module (3 × 3, 4 × 4, and 5 × 5) using an electroplating technique. The cup-shaped copper sheets were directly contacted with sapphire to enhance the heat dissipation of the chip itself. The lateral emitting light extraction and heat dissipation of high-power LEDs ...

Carcinoma of unknown primary (CUP) remains a common and challenging clinical problem. The aim of diagnostic work-up in CUP is to classify as specifically as possible the cancer affecting the patient, according to the broad tumour type, subtype and, where possible, site of origin. This classification currently best predicts patient outcome and guides optimal treatment. a stepwise approach to dia...

A concept of unique peptides (CUP) was proposed and implemented to identify whole-cell proteins from tandem mass spectrometry (MS/MS) ion spectra. A unique peptide is defined as a peptide, irrespective of its length, that exists only in one protein of a proteome of interest, despite the fact that this peptide may appear more than once in the same protein. Integrating CUP, a two-step whole-cell ...

The misregulation of programmed cell death, or apoptosis, contributes to the pathogenesis of many diseases. We used Nomarski microscopy to screen for mutants containing refractile cell corpses in a C. elegans strain in which all programmed cell death is blocked and such corpses are absent. We isolated a mutant strain that accumulates refractile bodies resembling irregular cell corpses. We rescu...

Granulocyte colony-stimulating factor (G-CSF)-producing nonhematopoietic malignancies have been reported in various organs and are associated with a poor clinical outcome. Moreover, carcinoma of unknown primary site (CUP) is an uncommon malignancy that occurs in about 2-6% of cancer patients. CUP also has a poor prognosis due to its missing profile. Since both G-CSF-producing carcinoma and CUP ...

Acetabular component orientation is influenced not only by the orientation at which the surgeon implants the component but also the orientation of the pelvis at the time of impaction. Hence, the orientation of the pelvis at set-up and its movement during the operation are critically important. Using a validated photogrammetric technique, during 67 hip arthroplasties, we measured how 3 surgeons ...

Cancer of unknown primary (CUP) site is a clinical syndrome that includes many types of advanced cancers. Patients are considered to have CUP if no anatomical primary site is identified after clinical evaluation. As diagnostic techniques improve, the spectrum of patients with CUP continues to evolve. Patients with CUP are common. The exact incidence is unknown because many of these patients are...

INTRODUCTION In cementless hip arthroplasty fixation of acetabular cups is often achieved using a press-fit between the cup and the bone, where the acetabulum is typically under-reamed by 1-4mm [1-4] with respect to the size of the cup. Deformation of the cups during insertion remains a concern as it could lead to changes in the clearance and sphericity of the bearing, which can adversely affec...