background: progesterone as a sex steroid hormone is thought to affect and prevent demyelination, but its role in promoting myelin repair is far less investigated. in this study, remyelinating potential of progesterone in corpus callosum was evaluated on an experimental model of ms. methods: in this experimental study, adult male c57bl/6 mice were fed with 0.2% (w/w) cuprizone in ground breeder...

multiple sclerosis is an autoimmune cns-disease characterized by inflammatory neurodegenerative events occurring with de- and remyelination. recent evidence show that demyelinated neurons are less excitable than myelinated ones while at early stages of remyelination these neurons seem to be hyperexcitable. the latter is a transitory condition that, very likely, leads to impaired neuronal networ...