We propose a method to engineer the genome of bacteriophages to increase their effectiveness as antibacterial agents. Specifically, we exploit the redundancy of the triplet code to design genomes that avoid restriction sites while producing the same proteins as wild-type phages. We give an efficient algorithm to minimize the number of restriction sites against sets of cutter sequences, and demo...

mowing. It is run along the ground on one large wheel which is f ree of the motor operat ing the cutter bar. I t can be tilted to cut up or down slopes and can be pivoted sharply in any direction. It has been found part icularly valuable for cutting around trees, boulders, t raps, creek-bottoms, and other golf course obstructions which formerly required hand cutt ing. The motor scythe, powered ...

Industrial robots are used in a great variety of applications for handling, welding and milling operations. They represent a cost-saving and flexible alternative for machining applications. A reduced pose and path accuracy, especially under process force load due to the high mechanical compliance, restrict the use of industrial robots for further machining applications. In this paper a method i...

Since the initial report on pars plana vitrectomy (PPV) for macular holes in 1991 by Kelly and Wendell [1], vitreous surgery has been established as a standard treatment for macular holes. The main goal of surgical management is removing tangential and anterior–posterior traction around the hole and immobilization and connection of hole edges. Therefore posterior hyaloid, the ILM, and epiretina...

To achieve high precision and high productivity in machining sculptured surfaces, a new architecture for a five-axis CNC interpolator for machining ruled surfaces was developed and demonstrated on a milling machine. The objective of the five-axis interpolator is to continuously maintain the milling cutter axis in parallel with the straight lines of the ruled surface. The cutter position and ori...

A novel optimization methodology for the disc cutter designs of tunnel boring machines (TBM) was presented. To fully understand the characteristics and performance of TBM cutters, a comprehensive list of performance parameters were investigated, including maximum equivalent stress and strain, specific energy and wear life which were closely related to the cutting forces and profile geometry of ...

This paper presents a method for on-line fault monitoring and diagnosis, which is implemented in the hydraulic control system in the cutter module of an industrial fish processing machine. Raw data from the pressure sensors and displacement sensors of the machine are analyzed on line, and residual values are generated using an Unscented Kalman Filter (UKF). By comparing these values against a s...

62 Management Summary In this paper a new method for the introduction of optimal modifications into gear tooth surfaces—based on the optimal corrections of the profile and diameter of the head cutter, and optimal variation of machine tool settings for pinion and gear finishing—is presented. The goal of these tooth modifications is the achievement of a more favorable load distribution and reduce...

We present the case of a 72-year-old woman diagnosed with rheumatic fever at the age of 6. In 1972, she was diagnosed with mitral valve insufficiency and mitral valve stenosis, then in 1974, a decision was made to perform mitral valve replacement surgery with a 32-mm Braunwald-Cutter ball cage prosthesis. An echocardiogram performed in 2014 revealed normal biventricular systolic function, mecha...

With the rapid development of high-precision-device technology, new demands are put forward for micro milling. The size effect and low cutting energy milling make process expensive difficult, especially Ti-6Al-4V alloys. wear micro-milling cutter lacks corresponding international standards its mechanism is complex. In this paper, four kinds cutters with different states were obtained by designi...