As one of the most intensively studied transcription factors, it is unsurprising that p53 is involved in many biological processes, including cell cycle arrest, DNA repair, senescence and apoptosis.1 its activities are mainly regulated by posttranslational modifications and interactions with other cellular components. Over the past few years, p53 has also been linked to redox homeostasis, the b...

One of the first responses of plants to microbial attack is the production of extracellular superoxide surrounding infection sites. Here, we report that Magnaporthe grisea, the causal agent of rice blast disease, undergoes an oxidative burst of its own during plant infection, which is associated with its development of specialized infection structures called appressoria. Scavenging of these oxy...

The aim of the study was to analyze how the expression of MCP-1, HIF-1α, NOX2, ERK1, ERK2, and Mn-SOD mRNA, which are related to inflammation and oxidative stress and which can influence the accumulation of macrophage in obese adipose tissue, differed according to a high-fat diet, change of diet composition, and exercise. Obesity was induced using a high-fat diet (45% fat) for five weeks. This ...

NADPH oxidases (NOX) catalyze the production of superoxides, a type of reactive oxygen species (ROS). The dramatic induction of ROS production by human NOX2 in activated blood phagocytic cells and its role in promoting pathogen killing has long motivated research in this area (Babior et al., 2002). In plants, the NOX homologs have been named respiratory burst oxidase homologs (Rboh) and they ar...

NADPH oxidase 4 (Nox4) has recently been implicated as driving force in cellular senescence. Thus, there is growing interest to develop Nox4 inhibitors, which might be valuable agents for cosmeceutical applications. Alpine plants represent a valuable source for the identification of novel bioactive natural products with anti-ageing effects, especially substances that protect plants against UV r...

AIMS To elucidate the role of reactive oxygen species (ROS) in arthritis and to identify targets of arthritis treatment in conditions with different levels of oxidant stress. RESULTS Through establishing an arthritis model by injecting arthritogenic serum into wild-type and NADPH oxidase 2 (NOX2)-deficient mice, we found that arthritis had a neutrophilic infiltrate and was more severe in Ncf1...

I I I Cl Cl Clin in inic ica a a Me Me Medi di d ca ca ca, Sa Sa Sapi pi pien en enza z , , U U Univ v ver er ersi si sity ty ty o of f f Ro Ro ome me me, , It It Ital a y y Abstract: Background—Statins exert an antithrombotic effect in patients at risk of or with acute

Cell death implies morphological changes that may contribute to the progression of this process. In astrocytes, the mechanisms involving the cytoskeletal changes during cell death are not well explored. Although NADPH oxidase (NOX) has been described as being a critical factor in the production of ROS, not much information is available about the participation of NOX-derived ROS in the cell deat...

Oxidized low-density lipoprotein (oxLDL) promotes unregulated platelet activation in dyslipidemic disorders. Although oxLDL stimulates activatory signaling, it is unclear how these events drive accelerated thrombosis. Here, we describe a mechanism for oxLDL-mediated platelet hyperactivity that requires generation of reactive oxygen species (ROS). Under arterial flow, oxLDL triggered sustained g...

In type 2 diabetes, it has been proposed that pancreatic beta-cell dysfunction is promoted by oxidative stress caused by NADPH oxidase (NOX) overactivity. Five different NOX enzymes (NOX1-5) have been characterized, among which NOX1 and NOX2 have been proposed to negatively affect beta-cells, but the putative role of NOX4 in type 2 diabetes-associated beta-cell dysfunction and glucose intoleran...