This paper establishes a new fact about the compositional changes in the pool of unemployed over the U.S. business cycle. Using micro-data from the Current Population Survey for the years 1962-2012, it documents that in recessions the pool of unemployed shifts towards workers with high wages in their previous job. These shifts are associated with both observed and unobserved factors in the wage...

Vomiting and abdominal pain are symptoms that may arise from a number of different causes. Cyclical vomiting and abdominal migraine are terms that have been applied to a presentation characterized by its episodic pattern and intervals of complete health. The 2 share many clinical features, but it is important to distinguish them as they have different responses to therapies such as prophylactic...

We studied 56 patients with fractures of the tibial shaft in a multicentre prospective randomised trial of three methods of external fixation. Group I was treated with a fixator which was unlocked at 4 to 6 weeks to allow free axial compression (axial dynamisation) with weight-bearing. Group II was treated with a fixator that was similarly unlocked at 4 to 6 weeks but included a small silicone ...

Sales forecasting is a common topic in business. Our task is predicting a famous drug company daily sales for 1,115 stores located across Germany for six weeks in advance. Store sales are influenced by many factors. Our project aims to create a robust prediction model. Based on Gradient Boosting and Random Forest, our model performs well in this sales forecasting competition with resulting in r...

In November, 1963, a small private symposium met at Johns Hopkins Univers^ to explore what were the major problems in making safe and effective drugs avails. from both the academic and industrial fields were present. In addition, the gt?f. included economists, the president of a drug company, lawyers and an Eng'1^ social scientist (Professor Richard Titmuss). In the course of their deliberation...

I n global-health politics, cardiovascular disease is the elephant in the room—a massive problem that few want to acknowledge and even fewer want to tackle. In [a recent issue of] Lancet, Carlene Lawes and colleagues, on behalf of the International Society of Hypertension, estimate that bloodpressure-related diseases cause about half this burden, killing around 8 million people each year.1 Low-...

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Highlights Q The Good: Sweeping reform plan does not pass because it is too costly to be financed without huge taxes. But, healthcare disinflation continues; drug companies keep their pricing increases to CPI or CPI + 1%. Health supply/device stocks unit growth flattens, but best companies still achieve 12-15% growth. Firms withdraw from marginal businesses, trim sales forces/product lines and ...

Dr. Salk's professional life was as far removed from that oftoday's researchers at the National Institutes ofHealth as the sun is from, say, Wall Street. Theoretically, the NIH belongs to the American people. U.S. taxpayers give it $28 billion a year to develop remedies for human misery. Many assume that today's NIH researchers are carrying on the mission as Salk did, free from financial or com...