نتایج جستجو برای: cyclo oxygenase 2

تعداد نتایج: 2533352  

Journal: :The European respiratory journal 1999
D N Watkins D J Peroni J C Lenzo D A Knight M J Garlepp P J Thompson

Cyclo-oxygenase is the rate-limiting enzyme in the prostanoid pathway. Although expression of the inducible isoform of cyclo-oxygenase (COX-2) is associated with cytokine-mediated inflammation, recent evidence suggests a homeostatic role for epithelial COX-2 in the gastrointestinal tract. The aim of this study was to examine the expression and localization of COX-2 in human airway epithelium bo...

Journal: :The Journal of clinical investigation 1980
P J Spagnuolo J J Ellner A Hassid M J Dunn

We examined the role of prostaglandins and thromboxanes as mediators of plasma-dependent increased polymorphonuclear leukocyte adhesiveness induced by Escherichia coli lipopolysaccharide. The cyclo-oxygenase inhibitors-indomethacin and d,l-6-chloro-alpha-methyl-carbozole-2-acetic acid (R020-5720)-reduced lipopolysaccharide-induced adherence of polymorphonuclear leukocytes by 74 and 62%, respect...

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