نتایج جستجو برای: cyclooxygenase cox
تعداد نتایج: 58101 فیلتر نتایج به سال:
Commentary It is well established that seizures, particularly status epilepti-cus (SE), induce upregulation of cyclooxygenase-2 (COX-2) in both neurons and non-neuronal cells (1, 2). COX-2 plays a role in seizure-induced leukocyte infiltration, astrogliosis, microg-lial activation, and breakdown of the blood-brain barrier (BBB); thus, COX-2 is clearly an important component of brain inflammatio...
Cyclooxygenases and lipoxygenases are proinflammatory enzymes; the former affects platelet aggregation, vasoconstriction, vasodilatation and later the development of atherosclerosis. Red wines from Georgia and central and western Europe inhibited cyclooxygenase-1 (COX-1) activity in the range of 63-94%, cyclooxygenase-2 (COX-2) activity in the range of 20-44% (tested at a concentration of 5 mL/...
Joint formation is a developmental process regulated by various factors including bone morphogenetic proteins, transforming and growth factors, etc. Recently, a high expression of cyclooxygenase (COX) isoforms in the foetal cartilaginous elements was also revealed. On the other hand, various joint and skeletal abnormalities were seen in laboratory animal and human offspring, exposed in utero to...
Gross, Gil, Takuji Imamura, Sherri K. Vogt, David F. Wozniak, D. Michael Nelson, Yoel Sadovsky, and Louis J. Muglia. Inhibition of cyclooxygenase-2 prevents inflammation-mediated preterm labor in the mouse. Am J Physiol Regulatory Integrative Comp Physiol 278: R1415–R1423, 2000.—Prostaglandins (PGs) have proven important during parturition, but inhibition of PG production treating preterm labor...
Non-steroidal anti-inflamatories (NSAIDs) are widely used in the treatment of post-surgery pain1, osteoarthritis2, rheumatoid arthritis3 and muscle-skeletal pain4,5, in different conditions. Major effects are: anti-inflammatory, analgesic, and antipyretic6. Generally speaking, such effects are associated to the inhibition of the enzyme cyclooxygenase (COX). COX catalyzes the transformation of a...
paraquat is a commonly used herbicide in many countries which can lead to systematic poisoning on exposure, in this study, paraquat (pq)-induced changes in the expression of cyclooxygenase-2 (cox-2) along with biochemical and histopathological changes in the lungs, liver and kidneys were studied. twenty four male wistar rats (180-200 g) were exposed either against saline as control group or var...
A series of ethyl 2-[2-arylamino-4-(thiophen-2-yl)thiazol-5-yl] acetates (5a-5k) and ethyl 2-[2-(arylhydrazino)-4-(thiophen-2-yl)thiazol-5-yl] acetates (9a-9g) were synthesized and screened for their anti-inflammatory, analgesic, and antioxidant activities. In vivo test results showed that the compounds with halogen substitution (5c, 5g, 5h, 5i and 5j) at the para position on the 2-aryl amino g...
AIM Cholestasis triggers fibrogenesis in the liver. Hepatic cyclooxygenase-2 (COX-2) expression increases in various chronic liver diseases caused either by viruses or toxins. We hypothesized that selective COX-2 inhibitor meloxicam could suppress inflammation and fibrogenesis in a rat model of cholestasis induced by bile duct ligation (BDL). METHODS Forty-three Sprague-Dawley rats were assig...
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