نتایج جستجو برای: cyclooxygenase cox

تعداد نتایج: 58101  

Journal: :Epilepsy currents 2012
F Edward Dudek

Commentary It is well established that seizures, particularly status epilepti-cus (SE), induce upregulation of cyclooxygenase-2 (COX-2) in both neurons and non-neuronal cells (1, 2). COX-2 plays a role in seizure-induced leukocyte infiltration, astrogliosis, microg-lial activation, and breakdown of the blood-brain barrier (BBB); thus, COX-2 is clearly an important component of brain inflammatio...

2014
Zsofia Kutil Veronika Temml David Maghradze Marie Pribylova Marcela Dvorakova Daniela Schuster Tomas Vanek Premysl Landa

Cyclooxygenases and lipoxygenases are proinflammatory enzymes; the former affects platelet aggregation, vasoconstriction, vasodilatation and later the development of atherosclerosis. Red wines from Georgia and central and western Europe inhibited cyclooxygenase-1 (COX-1) activity in the range of 63-94%, cyclooxygenase-2 (COX-2) activity in the range of 20-44% (tested at a concentration of 5 mL/...

Journal: :Folia morphologica 2009
F Burdan J Szumiło W Dworzański M Szumiło J Podlodowska K Dyndor B Madej J Dworzański R Klepacz

Joint formation is a developmental process regulated by various factors including bone morphogenetic proteins, transforming and growth factors, etc. Recently, a high expression of cyclooxygenase (COX) isoforms in the foetal cartilaginous elements was also revealed. On the other hand, various joint and skeletal abnormalities were seen in laboratory animal and human offspring, exposed in utero to...

2000
GIL GROSS TAKUJI IMAMURA SHERRI K. VOGT DAVID F. WOZNIAK D. MICHAEL NELSON YOEL SADOVSKY LOUIS J. MUGLIA Takuji Imamura Sherri K. Vogt David F. Wozniak D. Michael Nelson Yoel Sadovsky

Gross, Gil, Takuji Imamura, Sherri K. Vogt, David F. Wozniak, D. Michael Nelson, Yoel Sadovsky, and Louis J. Muglia. Inhibition of cyclooxygenase-2 prevents inflammation-mediated preterm labor in the mouse. Am J Physiol Regulatory Integrative Comp Physiol 278: R1415–R1423, 2000.—Prostaglandins (PGs) have proven important during parturition, but inhibition of PG production treating preterm labor...

Journal: :Arquivos brasileiros de cardiologia 2005
Leila Fernandes Araujo Alexandre de Matos Soeiro Juliano de Lara Fernandes Carlos Vicente Serrano Júnior

Non-steroidal anti-inflamatories (NSAIDs) are widely used in the treatment of post-surgery pain1, osteoarthritis2, rheumatoid arthritis3 and muscle-skeletal pain4,5, in different conditions. Major effects are: anti-inflammatory, analgesic, and antipyretic6. Generally speaking, such effects are associated to the inhibition of the enzyme cyclooxygenase (COX). COX catalyzes the transformation of a...

Journal: :iranian journal of pharmaceutical research 0
hassan malekinejad department of pharmacology and toxicology, faculty of veterinary medicine, p. o. box: 1177, urmia university, urmia, iran. aysa rezabakhsh department of pharmacology and toxicology, faculty of veterinary medicine, p. o. box: 1177, urmia university, urmia, iran. fatemeh rahmani department of molecular genetic, faculty of basic sciences, urmia university, urmia, iran. mazdak razi department of histology and embryology, faculty of veterinary medicine, urmia university, urmia, iran.

paraquat is a commonly used herbicide in many countries which can lead to systematic poisoning on exposure, in this study, paraquat (pq)-induced changes in the expression of cyclooxygenase-2 (cox-2) along with biochemical and histopathological changes in the lungs, liver and kidneys were studied. twenty four male wistar rats (180-200 g) were exposed either against saline as control group or var...

A series of ethyl 2-[2-arylamino-4-(thiophen-2-yl)thiazol-5-yl] acetates (5a-5k) and ethyl 2-[2-(arylhydrazino)-4-(thiophen-2-yl)thiazol-5-yl] acetates (9a-9g) were synthesized and screened for their anti-inflammatory, analgesic, and antioxidant activities. In vivo test results showed that the compounds with halogen substitution (5c, 5g, 5h, 5i and 5j) at the para position on the 2-aryl amino g...

Journal: :Hepatology research : the official journal of the Japan Society of Hepatology 2008
Seong Min Kim Ki Chung Park Ho Guen Kim Seok Joo Han

AIM Cholestasis triggers fibrogenesis in the liver. Hepatic cyclooxygenase-2 (COX-2) expression increases in various chronic liver diseases caused either by viruses or toxins. We hypothesized that selective COX-2 inhibitor meloxicam could suppress inflammation and fibrogenesis in a rat model of cholestasis induced by bile duct ligation (BDL). METHODS Forty-three Sprague-Dawley rats were assig...

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