Invivo Antidiabetic evaluation of Neem leaf extract in alloxan induced ratsShravan Kumar Dholi, Ramakrishna Raparla, Santhosh Mankala, Kannappan Nagappan

Artichoke (Cynara scolymus L.) is one of the world's oldest medicinal plants with multiple health benefits. We have previously shown that artichoke leaf extracts and artichoke flavonoids upregulate the gene expression of endothelial-type nitric oxide synthase (eNOS) in human endothelial cells. Whereas NO produced by the eNOS is a vasoprotective molecule, NO derived from the inducible iNOS plays...

In recent years a high demand for natural ingredients with nutraceutical properties has been witnessed, for which the development of more environmentally-friendly and cost-efficient extraction solvents and methods play a primary role. In this perspective, in this work, the application of deep eutectic solvents (DES), composed of quaternary ammonium salts and organic acids, as alternative solven...

One third of the artichoke production is used in industrial processes, where up to 70% 85% of the initial raw material is transformed into solid wastes. For an adequate management of these wastes, it is necessary to know their water sorption properties, because physical, chemical and biological changes which occur during their storage depend on water-solid interactions. The objectives of this w...

Nitric oxide (NO) produced by endothelial nitric-oxide synthase (eNOS) represents an antithrombotic and anti-atherosclerotic principle in the vasculature. Hence, an enhanced expression of eNOS in response to pharmacological interventions could provide protection against cardiovascular diseases. In EA.hy 926 cells, a cell line derived from human umbilical vein endothelial cells (HUVECs), an arti...

Nutraceuticals are an ever-expanding market worldwide, facing the unstoppable transition towards a green economy. Developing economically feasible and sustainable alternatives to current raw materials for extraction of nutraceuticals is, therefore, essential reach these goals and, at same time, achieve social economic competitiveness. This paper intends propose economical environmentally feedst...