نتایج جستجو برای: cytochrome p
تعداد نتایج: 1306848 فیلتر نتایج به سال:
The 7a-hydroxylation of taurodeoxycholic acid and the 6&hydroxylation of taurochenodeoxycholic acid and lithocholic acid were studied with a reconstituted system from rat liver microsomes consisting of partially purified cytochrome P-450, NADPH-cytochrome P-450 reductase, a synthetic phosphatidylcholine and NADPH or an NADPH-generating system. 7a-Hydroxylase activity was observed with cytochrom...
Cytochrome P-450 was purified to apparent homogeneity from the brain microsomes of phenobarbital-treated rats. The specific content of the purified P-450 was 12.7 nmol/mg of protein. NADPH-cytochrome P-450 reductase (reductase) was also purified to apparent homogeneity from brain microsomes. The specific content was 34.7,mol of cytochrome c reduced/min per mg of protein. The reduced carbon mono...
Introduction: Oxidative stress can impair the antioxidant protective capacity of the body, which is associated with decreased capacity of the body's internal defense system. There are some evidences that training and pumpkin seed (PS) consumption by different mechanisms have a protective effect on myocardial tissue by inhibiting oxidative stress. The aim of the present study was to investigate ...
Mechanism of inactivation of rat liver microsomal cytochrome P-450c by 2-bromo-4'-nitroacetophenone.
The mechanism by which 2-bromo-4'-nitroacetophenone (BrNAP) inactivates cytochrome P-450c, which involves alkylation primarily at Cys-292, is shown in the present study to involve an uncoupling of NADPH utilization and oxygen consumption from product formation. Alkylation of cytochrome P-450c with BrNAP markedly stimulated (approximately 30-fold) its rate of anaerobic reduction by NADPH-cytochr...
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