Introduction: Previous studies have demonstrated cytotoxic effects of Ferula assa-foetida. In the present study, anti-proliferative effect this plant on two species cancer cells related to pancreatic (MIA PaCa-2) and ovarian (SKOV-3) was investigated.

Background and objectives: Pterocarya fraxinifolia Lam. is a deciduous, fast-growing tree from walnut family. The stem barks and fruits of the plant have been used as diaphoretic in traditional medicine. Variation in the quantity and quality of the essential oil and extract of stems of the plant at different developmental stages was evaluated in addition to assessing t...

tribulus terrestris (tt) is a member of the zygophyllaceae family. traditional chinese medicine recommends the use of tt for treatment of a variety of diseases. in the present study we further investigated anti-proliferative and cytotoxic effects of tt extract on normal and several malignant cell lines. for this purpose, ttwas collected and after authentication, aqueous extract was prepared. cy...

Eucalyptus L. is traditionally used for many medicinal purposes. In particular, some Eucalyptus species have currently shown cytotoxic properties. Local Brazilian communities have used leaves of E. benthamii as a herbal remedy for various diseases, including cancer. Considering the lack of available data for supporting this cytotoxic effect, the goal of this paper was to study the in vitro cyto...

different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...

salvia is one of the largest genera of  lamiaceae family. several species of this genus are perfumed and wealthy in essential oils. some of them are used in industry, pharmacy and aromatherapy. they have shown different biological effects such as antibacterial and antioxidant activity. for the present study, salvia verticillata l. was collected from shahrestanak, mazandaran, iran. hydrodistille...

background: achillea talagonica (asteraceae) is an endemic herbaceous plant in iran with small yellow flowers and several times pinnately divided leaves in worm shape. the plant was found to be cytotoxic in our previous studies.   materials and methods: a. talagonica was collected in may 2005 from talegan in north of iran during the full flowering stage. dried aerial parts of the plant were red...

In search of better NSAIDs four novel nitric oxide donating derivatives of curcumin (compounds 9a-d), and four thiophene curcuminoids (compounds 10a-c, 11) have been synthesised. The cytotoxic effects of these compounds along with the lead compound curcumin (7) and their effect on the production of the reactive oxygen species nitric oxide and pro-inflammatory cytokines IL-1β, TNF-α and chemokin...

Epidemiological studies of Staphylococcus aureus have shown a relation between certain clones and the presence of specific virulence genes, but how this translates into virulence-associated functional responses is not fully elucidated. Here we addressed this issue by analyses of community-acquired S. aureus strains characterized with respect to antibiotic resistance, ST types, agr types, and vi...

OBJECTIVE The purpose of this in vitro study was to compare the cytotoxicity of 0.5-4.5 origanum extract solution (OES), 2% chlorhexidine gluconate (CHX) and 5.25% sodium hypochlorite (NaOCl) with WST-1 test on human periodontal ligament (hPDL) fibroblasts. MATERIALS AND METHODS About 0.5-4.5% OES, 2% CHX and 5.25% NaOCl solutions cytotoxicity was evaluated with cell culture test using PDL fi...