Allograft rejection is a T cell-dependent process. Productive T cell activation by antigen requires antigen engagement of the T cell receptor as well as costimulatory signals delivered through other T cell surface molecules such as CD28. Engagement of CD28 by its natural ligand B7 can be blocked using a soluble recombinant fusion protein, CTLA4Ig. Administration of CTLA4Ig blocks antigen-specif...

Bone marrow (BM)-derived antigen-presenting cells (APCs) are potent stimulators of T cell immune responses. We investigated the requirements for antigen presentation by these cells in priming cytotoxic T lymphocyte (CTL) responses to intracellular bacterial and viral pathogens. [Parent-->F(1)] radiation BM chimeras were constructed using C57BL/6 donors and (C57BL/6 x BALB/c)F(1) recipients. Inf...

Hepatitis B virus co-infection with C and/or D is known to result in a more deleterious disease than chronic HBV mono-infection, resulting faster progression cirrhosis and hepatocellular carcinoma. This study aimed at determining the serological prevalence of infections among carriers frequency e Antigen tertiary hospital South-East, Nigeria. cross-sectional involving 72 consenting participants...

background: sen virus (senv) is the latest virus proposed as a cause of unknown hepatitis cases. among nine detected genotypes of the virus, genotypes d and h are more frequent in hepatitis cases of unknown origin. the aim of this study was to determine the frequency of senv-d and senv-h genotypes in the sera of healthy individuals and hepatitis b and c patients. methods: totally, 200 serum sam...