Background: Methotrexate (MTX) intolerance refers to unpleasant symptoms that accompany use of MTX and may lead its discontinuation. However, it lacks a validated score in RA patients; with the only option being MISS which was for children not adults. Objectives: To develop validate questionnaire (s) measuring severity rheumatoid arthritis. Methods: A 10-item called ‘Methotrexate Intolerance Se...

The aim of the study was to assess the ability of the European Community Respiratory Health Survey (ECRHS) questionnaire to provide data on the prevalence, type and reported symptoms associated with food intolerance from a group of young adults in Melbourne. Six hundred and sixty nine randomly selected subjects completed the questionnaire with 553 attending the laboratory for skin-prick tests, ...

BACKGROUND Lactose malabsorption is variably associated with lactose intolerance (LI). The determinants of symptom onset have not yet been completely identified. Visceral sensitivity may play a role in the pathogenesis of functional symptoms; an increasing bulk of clinical and research data suggests the importance of the brain-gut interaction in intestinal bowel syndrome. AIM: To assess the imp...

Background: The identification of autonomic comorbidity in adolescents with headaches could provide additional treatment strategies. The objective of this study was to identify and quantify autonomic symptoms in adolescents with headaches during a clinic visit using the COMPASS 31 questionnaire. Methods: The Institutional Review Board at Greenville Health System approved chart review of 92 adol...

OBJECTIVES The objective was to characterise and identify potential risk factors for intolerance to multi-drug leprosy therapy (MDT) which prompted a medication change in a leprosy referral centre in northeastern Brazil. DESIGN A retrospective chart review of leprosy patients treated at a state referral centre for leprosy in Natal, Rio Grande do Norte, Brazil was completed. Chart review focus...

Adverse reactions to foods, aside from those considered toxic, are caused by a particular individual intolerance towards commonly tolerated foods. Intolerance derived from an immunological mechanism is referred to as Food Allergy, the non-immunological form is called Food Intolerance. IgE-mediated food allergy is the most common and dangerous type of adverse food reaction. It is initiated by an...

PURPOSE To determine whether intolerance to contact lens wear is attributable to clinical or protein characteristics of the tear film. METHODS Thirty-eight subjects participated; 20 were successful contact lens wearers and 18 had discontinued contact lens wear because of discomfort. Baseline tear film (no lens wear) was analyzed with a range of clinical measurements and protein analyses (lact...

BACKGROUND Orthostatic intolerance is development of symptoms during upright standing relieved by recumbency. An individual's predisposition to orthostatic intolerance (development of symptoms during upright posture) can be identified by Head-up Tilt Test (HUT). The aim of the present study was to compare the diagnostic yield (Percentage of patients tested positive) of short duration with conve...

Milk is an important source of high quality protein, energy, calcium, potassium, phosphorus and riboflavin. It also has good functional properties and a highly acceptable taste, making milk a good alternative for the nutrition of children and for food programmes in developing countries. However, in some instances it has been advocated that milk or milk based products might not be appropriate fo...

Objective: To evaluate the prevalence, symptoms, spontaneous course, and behavioral consequences of visual height intolerance in children in comparison to adults. Methods: Survey in three primary schools on the frequency of visual height intolerance in 455 children aged 8 to 10 years. Individual structured interviews of 90 susceptible children and 54 of their parents. Results: The prevalence of...