The aim of this study was to assess the aorta-intima thickness (aIT) and serum metabolomic profile in selective intrauterine growth-restricted (sIUGR) monochorionic diamniotic (MCDA) twin fetuses presenting Doppler velocimetry alterations. Fetal abdominal aIT was measured by ultrasound at 32 weeks of gestation, enrolling 24 MCDA twin fetuses (8 sIUGR and 16 controls). sIUGR twin fetuses were cl...

Objective. In the present study, since PON1 is known as an HDL-associated antioxidant enzyme that inhibits the oxidative modification of LDL and oxidative stress plays a role in the pathogenesis of mesenteric ischemia, we investigated the changes in PON1 activity and lipid profile in an experimental ischemic colitis model. Methods. Forty male Wistar albino rats were divided into two groups: the...

Kinases are heavily pursued pharmaceutical targets because of their mechanistic role in many diseases. Small molecule kinase inhibitors (SMKIs) are a compound class that includes marketed drugs and compounds in various stages of drug development. While effective, many SMKIs have been associated with toxicity including chromosomal damage. Screening for kinase-mediated toxicity as early as possib...

BACKGROUND AND AIMS An impaired lipid metabolism is often observed in patients with chronic liver diseases. To determine lipid profile in patients with cirrhosis and to asses if it relates to the severity of the cirrhosis. MATERIALS AND METHODS In an analytical cross-sectional study, 50 patients with cirrhosis (case) and 50 age- and sex matched healthy normolipidemic patients (comparison) wer...

A bioclimate model predicting the presence or absence of aspen, Populus tremuloides, in western USA from climate variables was developed by using the Random Forests classification tree on Forest Inventory data from about 118,000 permanent sample plots. A reasonably parsimonious model used eight predictors to describe aspen’s climate profile. Classification errors averaged 4.5%, most of which we...

Clustered DNA damages-two or more closely spaced damages (strand breaks, abasic sites, or oxidized bases) on opposing strands-are suspects as critical lesions producing lethal and mutagenic effects of ionizing radiation. However, as a result of the lack of methods for measuring damage clusters induced by ionizing radiation in genomic DNA, neither the frequencies of their production by physiolog...

In this paper, progressive damage and global failure of composite laminates under quasi-static, monotonic loading are investigated using 3D continuum damage mechanics. For this purpose, a finite element program has been developed using an eight-node 2D layered element including layer-wise plate theory. Damage analysis of a single orthotropic layer under various uniform in-plane and transverse l...

background and aims. oral lichen planus (olp) is an immunologic disorder. a large number of studies have reported that lipid rafts have a key role in receptor signaling of lymphocytes. here, we explore the potential of lipid rafts as targets for the development of a new class of agents to down-modulate immune responses and treat autoimmune diseases. materials and methods. the present cross-sect...

ramadan fasting during the month of ramadan is a religious obligation, practiced by millions of people around the world. ramadan fasting is essentially a fundamental change in lifestyle for one lunar month. this type of fasting may have significant effects on lipid profile. although there is no scientific consensus about the effects of fasting on cardiovascular risks such as changes in lipid pr...