To the editor: We read with great interest work of Tré-Hardy et al.1Tré-Hardy M. Cupaiolo R. Papleux E. Wilmet A. Horeanga Antoine-Moussiaux T. Vecchia A.D. al.Reactogenicity, safety and antibody response, after one two doses mRNA-1273 in seronegative seropositive healthcare workers.J Infect. 2021; S0163-4453 (-4Epub ahead print): 00158https://doi.org/10.1016/j.jinf.2021.03.025Abstract Full Tex...

Synthetic strategies that can precisely control the number and spatial arrangement of entanglements within topologically complex molecules are critical to development molecular nanotopology. In this issue Chem, Nistchke co-workers describe construction a 819 knot by using an extended circular helicate. The topological chirality resulting is controlled with enantiopure diamine building block. el...

Although items exhibiting topology are ubiquitous in everyday life, the realization of at nanoscale level relies on innovative synthetic strategies. A molecular weaving strategy, recently reported Nature Chemistry and by Leigh co-workers, has outlined precise synthesis a 74 knot two-dimensional fabric. These breakthroughs hard heels each other open up new route for incorporating predictable, we...

Knots are ubiquitous in the macroscopic world, with uses ranging from tying shoelaces to fishing, and they transform properties of thing that is tied. similarly found at nanoscale: for example, proteins DNA, also man-made polymers. These molecular entanglements, likewise, control molecules which tied—chain breakage polymers occurs most readily knotted point, knotting biomolecules can enhance st...

Since the beginning of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, there has been international concern about emergence virus variants with mutations that increase transmissibility, enhance escape from human immune response, or otherwise alter biologically important phenotypes. In late 2020, several emerged globally, including UK variant (B.1.1.7), South Africa (B.1.3...