One purpose of the present study was to evaluate the ability of 7-wk-old spontaneously hypertensive rats (SHR) to reset tubuloglomerular feedback (TGF) activity in response to acute volume expansion (VE). Second, we evaluated the contribution of ANG II, via its action on AT1 receptors, to TGF control of glomerular function during VE. TGF was assessed by micropuncture methods and proximal tubula...

Avoidance behaviors, in which a learned response causes omission of an upcoming punisher, are a core feature of many psychiatric disorders. While reinforcement learning (RL) models have been widely used to study the development of appetitive behaviors, less attention has been paid to avoidance. Here, we present a RL model of lever-press avoidance learning in Sprague-Dawley (SD) rats and in the ...

Dysregulation of brain-derived neurotrophic factor (BDNF), behavioral inhibition temperament (BI), and small hippocampal volume have been linked to anxiety disorders. Individuals with BI show facilitated acquisition of the classically conditioned eyeblink response (CCER) as compared to non-BI individuals, and a similar pattern is seen in an animal model of BI, the Wistar-Kyoto (WKY) rat. The pr...

The relationship between dietary fat and mammary carcinogenesis was examined by feeding a high-fat or a low-fat purified diet, differing only in fat and carbohydrate content, to Fischer, Long-Evans, and Sprague-Dawley rats. An additional group of rats from each strain was fed a nonpurified laboratory diet for comparison. The rats were given an i.v. dose of A/-nitrosomethylurea (50 mg/kg body we...

This study investigates changes in systolic and diastolic blood pressure Sprague Dawley rat dams exposed to postpartum stress. Eighteen pregnant were randomly divided into three groups: Control (C, n = 6, no-stress), Maternal Separation (MS, 6), Brief (BMS, 6). The pups group C housed under standard conditions their cages at the animal facility during period. From day 2 14, MS BMS separated fro...

Purpose: To study the effect of berberine on serum hormonal levels, endometrial gene, and protein signaling in a rat model polycystic ovary syndrome (PCOS).Methods: Eighty-seven healthy female Sprague Dawley (SD) rats were assigned to control group, PCOS each with 29 rats. The three groups: control, model, groups, A was established via administration letrozole (1 mg/kg) group continuously for 2...

The hypothesis that BHE/Cdb rats with mutations in their mitochondrial genome might accommodate this mutation by changing their food intake patterns was tested. Four experiments were conducted. Experiments 1 and 2 examined food intake patterns of BHE/Cdb rats fed a stock diet or BHE/Cdb and Sprague-Dawley rats fed a high-fat diet from weaning. Experiment 3 examined the daily rhythms of respirat...

The relationship between dietary fat and mammary carcinogenesis was examined by feeding a high-fat or a low-fat purified diet, differing only in fat and carbohydrate content, to Fischer, Long-Evans, and Sprague-Dawley rats. An additional group of rats from each strain was fed a nonpurified laboratory diet for comparison. The rats were given an i.v. dose of N-nitrosomethylurea (50 mg/kg body wei...

Garlic and its derivative preparations have long been used in traditional medicine for good health. is known to act as an antioxidant, antitumor, antibacterial, antifungal. The antioxidant compound singlebulb garlic considered be better than the content other species of garlic. This research aimed study effect hematological profile oral administration single-bulb extract e-cigarette-induced mal...