Guanine nucleotides are key players in mediating growth-cone signaling during neural development. The supply of cellular guanine nucleotides in animals can be achieved via the de novo synthesis and salvage pathways. The de novo synthesis of guanine nucleotides is required for lymphocyte proliferation in animals. Whether the de novo synthesis pathway is essential for any other cellular processes...

Methylation of cytosine residues in DNA plays an important role in regulating gene expression during vertebrate embryonic development. Conversely, disruption of normal patterns of methylation is common in tumors and occurs early in progression of some human cancers. In vertebrates, it appears that the same DNA methyltransferase maintains preexisting patterns of methylation during DNA replicatio...

BACKGROUND De novo cancers are a growing problem that has become one of the leading causes of late mortality after liver transplantation. The incidences and risk factors varied among literatures and fewer concerned the Eastern population. AIMS The aim of this study was to examine the incidence and clinical features of de novo cancers after liver transplantation in a single Chinese center. M...

Cardiovascular disease (CVD) is the major cause of death in renal transplant recipients (RTR). Several cohort studies have examined CVD in RTR, but none have addressed the development of congestive heart failure (CHF). CHF would hypothetically be a frequent and prognostically important event in RTR. A retrolective cohort study was, therefore, conducted in two Canadian centers to describe the in...

A well-known mechanism through which new protein-coding genes originate is by modification of pre-existing genes, e.g. by duplication or horizontal transfer. In contrast, many viruses generate protein-coding genes de novo, via the overprinting of a new reading frame onto an existing ("ancestral") frame. This mechanism is thought to play an important role in viral pathogenicity, but has been poo...

We examine the hypothesis that de novo template-free RNAs still form spontaneously, as they did at the origins of life, invade modern genomes, contribute new genetic material. Previously, analyses of RNA secondary structures suggested that some RNAs resembling ancestral (t)RNAs formed recently de novo, other parasitic sequences cluster with rRNAs. Here positive control analyses of additional RN...

Introduction: The six-minute walking test distance, despite being considered the main parameter, does not consider body weight which is known to influence exercise capacity. A body of evidence * Professor do Centro Universitário Feevale de Novo Hamburgo/ Médico pneumologista do Pavilhão Pereira Filho/ Professor do Programa de Pós Graduação em Ciências Pneumológicas da Universidade Federal do Ri...

Fatty acids can be synthesized in mitochondrial membranes of rat liver either by elongation or by synthesis de nouo. The outer membranes incorporate greater amounts of substrate into fatty acids than do the inner membranes. Outer membranes synthesize 6and g-carbon fatty acids completely de nouo, while smaller amounts of lo-carbon acids are produced by the mechanism de novo. The reactions de nov...

Fatty acids can be synthesized in mitochondrial membranes of rat liver either by elongation or by synthesis de nouo. The outer membranes incorporate greater amounts of substrate into fatty acids than do the inner membranes. Outer membranes synthesize 6and g-carbon fatty acids completely de nouo, while smaller amounts of lo-carbon acids are produced by the mechanism de novo. The reactions de nov...

Peroxisomes are considered to form either by growth and division of existing peroxisomes or de novo from the endoplasmic reticulum. A recent study now demonstrates that mitochondria-derived vesicles are also required for de novo peroxisome biogenesis.