We studied the effect of treatment with diethylcarbamazine (DEC) on immune responses to parasite antigens in humans infected with Brugia malayi. In vitro lymphocyte proliferative responses to microfilarial antigens increased in patients who became amicrofilaremic after treatment with DEC. No changes in reactivity were observed in amicrofilaremic individuals who were given DEC or in a small numb...

Diethylcarbamazine (DEC) produced an initial stimulation followed by depression of the movements of the intact worm and nerve-muscle preparation of Setaria cervi. The effective concentration of DEC was reduced to one hundredth in the nerve-muscle preparation as compared to the whole worm, suggesting that the cuticular barrier is highly effective in preventing the penetration of the drugs. The d...

INTRODUCTION Infectious diarrhoea particularly due to pathogenic bacteria is a major health problem in developing countries, including India. Despite significant reports of diarrhoeagenic Escherichia coli (DEC) pathotypes around the globe, studies which address genetic relatedness, antibiogram profile and their correlation with respect to their isolation from different sources are sparse. The p...

Diethylcarbamazine (DEC) is an antifilarial drug with potent anti-inflammatory properties as a result of its interference with the metabolism of arachidonic acid. The aim of the present study was to evaluate the anti-inflammatory activity of DEC in a mouse model of acute inflammation (carrageenan-induced pleurisy). The injection of carrageenan into the pleural cavity induced the accumulation of...

Background: Diethylcarbamazine citrate (DEC) is the drug of choice for the treatment of lymphatic filariasis, a disease which affects people in the tropical areas of the world. Mass treatment with DEC is recommended for control of lymphatic filariasis and in this connection, there is a need for an assay which could be used for the purpose of medication control. Objective: The present study is a...

Using qualitative ICT Filariasis and quantitative Og4C3 ELISA, we assessed a long-term macrofilaricidal effect of two-year biannual mass treatments with a 300 mg oral-dose FILADEC tablet, a reformulation of 6 mg/kg diethylcarbamazine (DEC), on clearance of the Wuchereria bancrofti adult worm circulating filarial antigens (CFA) in Myanmar migrants, at risk of emergence of imported bancroftian fi...

In 2010, the authors developed, tested, and released a reliable and valid instrument that can be used to assess the quality of inexperienced teachers’ TPACK by examining their detailed written lesson plans. In the current study, the same instrument was tested to see if it could be used to assess the TPACK evident in experienced teachers’ planning in the form of spoken responses to semi-structur...

This paper presents a method for discrete event controller (DEC) synthesis for a manipulation task modeled as a hybrid dynamic system (HDS). The modelling of a manipulation task as a HDS has been shown to be a very eeective strategy to incorporate the interaction of the robot manipulator with its environment. In addition, this modelling has allowed the derivation of realistic conditions on the ...

Expectation maximization (EM) has recently been shown to be an efficient algorithm for learning finite-state controllers (FSCs) in large decentralized POMDPs (Dec-POMDPs). However, current methods use fixed-size FSCs and often converge to maxima that are far from optimal. This paper considers a variable-size FSC to represent the local policy of each agent. These variable-size FSCs are construct...