نتایج جستجو برای: decellularization extracellular matrix

تعداد نتایج: 450604  

Journal: :Circulation Research 2005

Journal: :Circulation Research 2014

Journal: :The Annals of thoracic surgery 2013
John D O'Neill Rachel Anfang Annabelle Anandappa Joseph Costa Jeffrey Javidfar Holly M Wobma Gopal Singh Donald O Freytes Matthew D Bacchetta Joshua R Sonett Gordana Vunjak-Novakovic

BACKGROUND The only definitive treatment for end-stage organ failure is orthotopic transplantation. Lung extracellular matrix (LECM) holds great potential as a scaffold for lung tissue engineering because it retains the complex architecture, biomechanics, and topologic specificity of the lung. Decellularization of human lungs rejected from transplantation could provide "ideal" biologic scaffold...

2017
Muriel Meiring Mmakgabu Khemisi Leana Laker Pascal M. Dohmen Francis E. Smit

BACKGROUND The use of decellularized biological scaffolds for the reconstruction of small-diameter vascular grafts remains a challenge in tissue engineering. Thrombogenicity is an important cause of obstruction in these vessels due to decellularization. Seeding of the decellularized vascular constructs with endothelial cells is therefore a prerequisite for the prevention of thrombosis. The aim ...

2017
Shuangyue Xu Fangna Lu Lianna Cheng Chenglin Li Xu Zhou Yuan Wu Hongxing Chen Kaichuang Zhang Lumin Wang Junjie Xia Guoliang Yan Zhongquan Qi

BACKGROUND The development of a suitable extracellular matrix (ECM) scaffold is the first step in vascular tissue engineering (VTE). Synthetic vascular grafts are available as an alternative to autologous vessels in large-diameter arteries (>8 mm) and medium-diameter arteries (6-8 mm). In small-diameter vessels (<6 mm), synthetic vascular grafts are of limited use due to poor patency rates. Com...

Journal: :Biomaterials science 2017
Gigi Chi Ting Au-Yeung Udi Sarig Hadar Sarig Hanumakumar Bogireddi Tomer Bronshtein Limor Baruch Avihai Spizzichino Jacob Bortman Boey Yin Chiang Freddy Marcelle Machluf Subbu S Venkatraman

Various extracellular matrix (ECM) scaffolds, isolated through decellularization, were suggested as ideal biomimetic materials for 'Functional tissue engineering' (FTE). The decellularization process comprises a compromise between damaging and preserving the ultrastructure and composition of ECM-previously shown to affect cell survival, proliferation, migration, organization, differentiation an...

Journal: :Biomaterials 2012
Yunqing Kang Sungwoo Kim Julius Bishop Ali Khademhosseini Yunzhi Yang

Extracellular matrix (ECM) serves a key role in cell migration, attachment, and cell development. Here we report that ECM derived from human umbilical vein endothelial cells (HUVEC) promoted osteogenic differentiation of human bone marrow mesenchymal stem cells (hMSC). We first produced an HUVEC-derived ECM on a three-dimensional (3D) beta-tricalcium phosphate (β-TCP) scaffold by HUVEC seeding,...

2017
Susanne Pauline Roth Sina Marie Glauche Amelie Plenge Ina Erbe Sandra Heller Janina Burk

BACKGROUND Decellularization of tendon tissue plays a pivotal role in current tissue engineering approaches for in vitro research as well as for translation of graft-based tendon restoration into clinics. Automation of essential decellularization steps like freeze-thawing is crucial for the development of more standardized decellularization protocols and commercial graft production under good m...

Journal: :Circulation journal : official journal of the Japanese Circulation Society 2013
Alexander Weymann Bastian Schmack Takayuki Okada Pál Soós Roland Istók Tamás Radovits Beate Straub Enikö Barnucz Sivakkanan Loganathan Ines Pätzold Nicole Chaimow Carsten Schies Sevil Korkmaz Ursula Tochtermann Matthias Karck Gábor Szabó

BACKGROUND Heart valve tissue engineering represents a concept for improving the current methods of valvular heart disease therapy. The aim of this study was to develop tissue engineered heart valves combining human umbilical vein endothelial cells (HUVECs) and decellularized human heart valve matrices. METHODS AND RESULTS Pulmonary (n=9) and aortic (n=6) human allografts were harvested from ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Amandine F G Godier-Furnémont Timothy P Martens Michael S Koeckert Leo Wan Jonathan Parks Kotaro Arai Geping Zhang Barry Hudson Shunichi Homma Gordana Vunjak-Novakovic

Control over cell engraftment, survival, and function remains critical for heart repair. We have established a tissue engineering platform for the delivery of human mesenchymal progenitor cells (MPCs) by a fully biological composite scaffold. Specifically, we developed a method for complete decellularization of human myocardium that leaves intact most elements of the extracellular matrix, as we...

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