NPR1 is a key transcriptional coregulator in plant defense responses. In this issue, Spoel et al. (2009) demonstrate that proteasome-mediated degradation of NPR1 in the nucleus promotes efficient expression of defense response genes following infection and prevents spurious activation of defensive responses in the absence of infection.

Recent studies on the interactions between plants and pathogenic microorganisms indicate that the processes of disease symptom development and pathogen growth can be uncoupled. Thus, in many instances, the symptoms associated with disease represent an active host response to the presence of a pathogen. These host responses are frequently mediated by phytohormones. For example, ethylene and sali...

The level of reactive oxygen species (ROS) increases under different stresses and, by destroying cellular components, may cause cell death. In addition, ROS are part of the complex network of transduction signals that induce defense reactions against stress or, alternatively, trigger programmed cell death, and key questions are the levels of each ROS that, respectively determine defense and dea...

" The book identifies the state-of-the-art tools and processes being used for cyber defense and highlights gaps in the technology. It presents the best practice of industry and government for incident detection and reponse and examines indicators and metrics for progress along the security continuum. "-Belfer Center (Harvard Kennedy School) The cyber security of vital infrastructure and service...

Tomato yellow leaf curl virus (TYLCV) threatens tomato production worldwide by causing leaf yellowing, leaf curling, plant stunting and flower abscission. The current understanding of the host plant defense response to this virus is very limited. Using whole transcriptome sequencing, we analyzed the differential gene expression in response to TYLCV infection in the TYLCV-resistant tomato breedi...

Non-host resistance (NHR) is a broad-spectrum plant defense. Upon colonizing on the surface on the root or leaves of non-host species, pathogens initial encounter preform and induce defense response in plant, such as induced hypersensitive response, PAMPs triggered immunity (PTI), and effector triggered immunity (ETI). The ability of plants to develop an induced systemic response (ISR) in react...

abstract in this study the relationship among perfectionism, defense styles and depression symptoms was studied. participants were 426 undergraduate students from the university of guilan (264 females, 162 males), who were selected through randomized clustering multistage method. all participants were asked to complete the multidimensional perfectionism scale (hewitt & flett, 1991), the defense...

Experimental studies in animal models supporting protective effects on the fetus of melatonin in adverse pregnancy have prompted clinical trials in human pregnancy complicated by fetal growth restriction. However, the effects of melatonin on the fetal defense to acute hypoxia, such as that which may occur during labor, remain unknown. This translational study tested the hypothesis, in vivo, tha...

The potential treatment of lung disease by delivery of exogenous DNA to cells for expression of therapeutic proteins is an exciting benefit of the recent revolution in molecular engineering (1–3). Adenovirus-based vectors have received considerable attention for DNA delivery to lung cells for several reasons: adenoviruses can infect nondividing cells in the airway epithelium; they are stable; t...

DNA damage plays a causal role in numerous human pathologies including cancer, premature aging, and chronic inflammatory conditions. In response to genotoxic insults, the DNA damage response (DDR) orchestrates DNA damage checkpoint activation and facilitates the removal of DNA lesions. The DDR can also arouse the immune system by for example inducing the expression of antimicrobial peptides as ...