The traditional role of iron chelation therapy has been to reduce body iron burden via chelation of excess metal from organs and fluids and its excretion via biliary-fecal and/or urinary routes. In their present use for hemosiderosis, chelation regimens might not be suitable for treating disorders of iron maldistribution, as those are characterized by toxic islands of siderosis appearing in a b...

OBJECTIVES Iron chelators, such as maltol and kojic acid, have antioxidant and anti-inflammatory properties. They may have beneficial effects on inflammatory bowel disease (IBD) because iron can develop and aggravate inflammation in IBD. In the present study, the effect of selected iron chelators and anti-oxidants were evaluated on a model of trinitrobenzene sulfonic acid (TNBS)-induced colitis...

Latar Belakang: Talasemia merupakan kelainan genetik dengan defisiensi sintesis salah satu dari dua tipe rantai polipeptida yang mempengaruhi kecepatan produksi globin spesifik dalam hemoglobin (Hb) disertai manifestasi klinis yaitu anemia berat. Pemberian transfusi secara berulang sebagai penatalaksanaan dapat menyebabkan kadar besi tubuh meningkat. Tujuan penelitian ini adalah mengetahui hubu...