Granulomatous inflammation plays a major role in the pathogenesis of a wide variety of diseases caused by infectious agents, including mycobacteria (tuberculosis, leprosy); fungi (coccidioidomycosis, histoplasmosis); worms (schistosomiasis, fllariasis) ; and possibly viruses and protozoa (1, 2). Although it has long been suspected that the granuloma may be a manifestation of delayed hypersensit...

Background: Plant extracts have been widely investigated for possible immunomodu-latory properties. Objective: To study the immunomodulatory functions of the metha-nol extract of Haussknechtia elymatica (Apioideae), an herb native to south-western Iran. Methods: Delayed type hypersensitivity (DTH) skin test and measurement of an-tibody titer after immunization with Sheep-RBC was performed. [3H]...

background: plant extracts have been widely investigated for possible immunomodu-latory properties. objective: to study the immunomodulatory functions of the metha-nol extract of haussknechtia elymatica (apioideae), an herb native to south-western iran. methods: delayed type hypersensitivity (dth) skin test and measurement of an-tibody titer after immunization with sheep-rbc was performed. [3h]...

Delayed-type hypersensitivity (DTH) 1 is a T cell-mediated reaction resulting in a mononuclear cell-rich inf lammat ion and swelling that peak 24-48 h after local antigenic challenge. In spite of the extensive use of D T H to dissect regulatory (1), genetic (2), and molecular (3) aspects of in vivo T cell responses, little is known of factors that regulate the persistence o f these reactions. I...

An antigen dose below the level needed to provoke an antibody response produces in mice a persistent, but minor degree of delayed-type hypersensitivity (dth) to sheep red blood cells. The DTH is unstable. It is erased by larger doses of antigen and cannot be built upon by further antigenic stimulation. The much higher levels of DTH resulting from immunization under the modulating influence of c...

although recently paradoxical potentiation of antibody titers has been reported (11, 14). Cancer chemotherapists have been concerned for many years that the drugs used in treating cancer might suppress any host immunity to the tumor and actually hasten rather than retard its spread. It was for this reason that the present study was under taken. Briefly, the experimental design consisted of asse...

The susceptibility of patients with Hodgkin's disease to mycotic and viral infections has long directed attention to an immunological defect in that condition (1). The early finding of tuberculin negativity in these patients (2, 3), even in the presence of active tuberculous infection, has been confirmed repeatedly. Subsequent investigations have indicated that this cutaneous anergy extends to ...

Corticosteroids are the most widely used class of drugs in dermatology. In the past, allergic contact dermatitis to topical corticosteriods was rarely reported. In this article, we present a case of delayed type hypersensitivity to triamcinolone acetonide.

Juvenile rheumatoid arthritis (JRA) is thought by many to be a different disease from rheumatoid arthritis in adults (RA), partly because of the infrequency of pathological serological phenomena (Calabro, 1966). Recent investigations have, however, shown that antigammaglobulin and antinuclear antibodies are often found in sera from patients with JRA (KAss and Munthe, 1969; Torrigiani, Ansell, C...

Cutaneous basophil hypersensitivity, an immune inflammatory reaction characterized by infiltrates of basophils and a delayed time-course, was studied in guinea pigs contact sensitized with oxazolone. Routine histological techniques, employing ordinary paraffin sections, were modified to study this reaction. When biopsies of contact lesions were processed by these methods dense infiltrates of ba...