BACKGROUND Drug resistance is one of the bottlenecks of cancer chemotherapy in the clinic. Polymeric nanomedicine is one of the most promising strategies for overcoming poor chemotherapy responses due to the multidrug resistance (MDR). METHODS In this study, a new polymer-based drug delivery system, poly (l-γ-glutamylglutamine)-doxorubicin (PGG-Dox) conjugate, was studied in both drug-induced...

Nonlinear conjugate gradient method is well known in solving large-scale unconstrained optimization problems due to it’s low storage requirement and simple to implement. Research activities on it’s application to handle higher dimensional systems of nonlinear equations are just beginning. This paper presents a Threeterm Conjugate Gradient algorithm for solving Large-Scale systems of nonlinear e...

In this paper we study multivariate polynomial functions in complex variables and the corresponding associated symmetric tensor representations. The focus is on finding conditions under which such complex polynomials/tensors always take real values. We introduce the notion of symmetric conjugate forms and general conjugate forms, and present characteristic conditions for such complex polynomial...

is an isomorphism. Here F : X −→ X denotes the Frobenius morphism on X and H denotes the a cohomology sheaf of F∗Ω•X . If the variety is not smooth, not much is known about the properties of the Cartier operator and the poor behaviour of the deRham complex in this case makes its study difficult. If one substitutes the deRham complex with the Zariski-deRham complex the situation is better. For e...

Previous work on probabilistic topic models has either focused on models with relatively simple conjugate priors that support Gibbs sampling or models with non-conjugate priors that typically require variational inference. Gibbs sampling is more accurate than variational inference and better supports the construction of composite models. We present a method for Gibbs sampling in non-conjugate l...

Abstract: OFDM (Orthogonal frequency division multiplexing) is a well known technique in 4G Broadband wireless communication systems. OFDM has high spectral efficiency but it suffers from frequency offset problem due to the difference between transmitter and receiver local oscillator frequencies which causes loss of orthogonality between subcarriers leading to ICI. This degrades the performance...

We investigate an iterative receiver with a linear detector for complex symbols to suppress the co-antenna interference introduced by a multiple input multiple output (MIMO) channel. For generalized MIMO systems, i.e., systems that transmit besides the pure data also complex conjugate repetitions, we show that the standard linear detector has to be replaced by a widely linear (WL) detector. The...