BACKGROUND Traditional subcutaneous immunotherapy up dosing with allergenic extracts has been shown to be associated with frequent adverse reactions. In recent studies it has been demonstrated that using modified extracts, namely allergoids, it is a safe and effective procedure particularly on accelerated schedules. However data assessing its safety in paediatric age is scarce. OBJECTIVE To e...

Reticulate acropigmentation of Kitamura (RAK) and Dowling-Degos Disease (DDD) are rare genodermatosis inherited as an autosomal dominant trait with variable penetrance. They are part of a spectrum of diseases with hyperpigmented macules coalescing in a reticular pattern, facial and palmoplantar pits, breaks in dermatoglyphics, comedo-like lesions and epidermoid cysts, and a unique histological ...

A 6-year-old boy presented with sudden onset of progressive, asymptomatic crops of well-demarcated, symmetrical, hypomelanotic macules ranging in size from 0.1 to 0.5 cm [Figures 1-3]. The eruption appeared in crops and began on the forearms and then spread to legs and thighs and face over a period of 1 week. Most lesions were non-scaly and discrete. Some closely situated macules showed conflue...

CASE REPORT A 9-year-old boy presented with multiple telangiectatic macular lesions since birth. Two telangiectatic macules, about 1 cm in diameter, were initially observed on the temples at birth, and then more and more similar lesions developed on the face, neck, trunk and extremities (Fig. 1). Physical examination revealed asymptomatic, scattered, oval, pinkish to erythematous telangiectatic...

A ten-year-old girl presented with swelling on left upper eyelid, multiple hyper pigmented macules and small nodular swellings with hair growth all over the body since birth. Examination revealed hyper pigmented macules >1 cm in diameter, numerous in numbers on both legs. Hyper pigmented nodular lesion was noted in left temporofacial area and swelling on left upper eyelid with restricted upward...

DOI: 10.1590/S1679-45082014AI2931 A previous healthy 7-year-old boy presenting occipital headache and constantly wake up at night with 1 week of evolution was admitted to our emergency service. He had linear hypopigmented macules along the lines of Blaschko affecting hemithorax and left upper limbs (Figure 1). The patient also had macrocrania, antimongoloid palpebral fissure, changes in left ey...

Dowling-Degos disease (DDD) is a rare genetic disease of the skin (reticulate pigmented anomaly), clinically characterized by flexural brown pigmented reticulate macules, comedo-like papules on the back, neck and pitted perioral or facial scars. We present the case of a 51 year-old man with macrocomedo-like lesions, pitted scars, cysts, hyperpigmented macules in his back, chest, axillae, neck, ...