An average mouse in midlife weighs between 25 and 30 g, with about a gram of tissue in the largest adipose depot (gonadal), and the weight of this depot differs between inbred strains. Specifically, C57BL/6ByJ mice have heavier gonadal depots on average than do 129P3/J mice. To understand the genetic contributions to this trait, we mapped several quantitative trait loci (QTLs) for gonadal depot...

Vehicle routing variants with multiple depots and mixed fleet present intricate combinatorial aspects related to sequencing choices, vehicle type choices, depot choices, and depots positioning. This paper introduces a dynamic programming methodology for efficiently evaluating compound neighborhoods combining sequence-based moves with an optimal choice of vehicle and depot, and an optimal determ...

BACKGROUND Naltrexone is an effective medication for treatment of alcohol dependence, but its efficacy is limited by lack of adherence to the oral dosage form. A long-acting depot formulation of naltrexone may increase adherence. METHODS A single site, 6-week open label study was conducted with 16 alcohol dependent subjects each receiving 300 mg of Naltrexone Depot by intramuscular injection....

background: benzene, toluene, ethylbenzene and xylene (btex) are the most important toxic volatile compounds in the air and could be easily absorbed through the respiratory tract. in recent years, the risk of exposure to btex compounds, especially benzene as a carcinogen, has been considered in petroleum depot stations. objective: to assess the occupational exposure of petroleum depot workers i...

Background: There are few studies on the anticholinergic side effects of long-acting antipsychotics. They tend to be used with stigmatized, severely ill and non-concordant patients rather than first episode psychosis. Aim: To investigate prevalence/incidence rate of anticholinergic side effects of long-acting antipsychotics. Methods: We included all participants with schizophrenia, schizoaffect...

We study the Multi-Depot Multiple Traveling Salesman Problem (MDMTSP), which is a variant of the very well-known Traveling Salesman Problem (TSP). In the MDMTSP an unlimited number of salesmen have to visit a set of customers using routes that can be based on a subset of available depots. The MDMTSP is an NPhard problem because it includes the TSP as a particular case when there is only one dep...

background & aim: sexual health is an essential element of quality of life, affecting both physical and psychological domains. hormones used in contraceptive methods have contradictory effects on sexual function. in this study, we aimed to compare sexual function in women using combined oral contraceptives (coc) and depot medroxyprogesterone acetate (dmpa), referred to healthcare centers affili...

The Vehicle Routing Problem (VRP) is a well studied logistical problem along with its various variants such as VRP customer Time-Window (VRPTW). However, all the previously assume that vehicles are mostly same in terms of their capacity, location and home (depot). This study uses agent-based approach for solving VRPTW vehicle’s unique depot. to minimise number used main target. Other targets in...

In this paper, we study the feasibility of sending drones to deliver goods from a depot customer by solving what call Mission-Feasibility Problem (MFP). Due payload constraints, drone can serve only one at time. To end, propose novel framework based on time-dependent cost graphs properly model MFP and tackle delivery dynamics. When moves in area, global wind may change thereby affecting drone's...

Background: These studies evaluated the safety and efficacy of a single-dose sustained release dexamethasone depot (DEXTENZATM, Intracanalicular Depot) for the treatment of pain and inflammation following cataract surgery. Methods: Patients were randomized (2:1) on Day 1 to receive a sustained release dexamethasone depot, (0.4 mg; Study 1, n=164; Study 2, n=161) or placebo vehicle depot (Study ...