We have constructed igtiO cDNA libraries from the mRNA of the human fetal lung cell line. Flow 2000 (Japanese Cancer Research Resources Bank JCRB0067), and isolated two cDNA clones which together contain the complete coding region for a tissue-type plasminogen activator (t-PA). Sequence analysis reveals variant nucleotides compared with those reported for the cDNAs (1,2,3) and genoraic DNAs (4,...