We describe a 50-year-old Japanese patient with dermatofibrosarcoma protuberans (DFSP) rapidly growing after bilateral adrenalectomy for Cushing's syndrome that reduced the serum level of cortisol from 17.1 to 0.8 mg/dl. It is known that glucocorticoids decrease the transcriptions of the COL1A1 gene and the PDGFB gene, which is under the direct control of the COL1A1 gene in most DFSP. Therefore...

Background: Only around 60% of skin lesions excised by GPs are referred to a pathologist. Clinical diagnoses of skin excisions by GPs may not be very accurate. Subcutis excisions are rarely done by GPs, and there is hence little information in the literature on the histopathological yield of subcutis excisions by GPs with regard to malignancies. The aim of this study was to evaluate the yield o...

σ pathway is involved in biofilm formation by Crohn’s disease-associated 1 adherent-invasive Escherichia coli 2 3 Benoit Chassaing and Arlette Darfeuille-Michaud 4 5 1 Clermont Université, UMR 1071 Inserm/Université Auvergne, Clermont-Ferrand 6 63000, France 7 2 INRA USC 2018, Clermont-Ferrand 63000, France 8 3 Centre Hospitalier Universitaire, Clermont-Ferrand 63000, France 9 10 11 Running tit...

If A(t) is a C1,α-curve of unbounded self-adjoint operators with compact resolvents and common domain of definition, then the eigenvalues can be parameterized C1 in t. If A is C∞ then the eigenvalues can be parameterized twice differentiable. Theorem. Let t 7→ A(t) for t ∈ R be a curve of unbounded self-adjoint operators in a Hilbert space with common domain of definition and with compact resol...

COL1A1: collagen 1 a1 DF: dermatofibroma DFSP: dermatofibrosarcoma protuberans FISH: fluorescence in situ hybridization JXG: juvenile xanthogranuloma PDGFB: platelet-derived growth factor-b INTRODUCTION Spindle cell tumors occur in the pediatric population and can prove to be aggressive clinically, as in the case with dermatofibrosarcoma protuberans (DFSP). Soft tissue sarcomas represent less t...

INTRODUCTION Excision of large dermatofibrosarcoma protuberans in the anterior aspect of the trunk often results in large surgical defects that frequently dictate the need for microsurgical reconstruction. However, this option is not always available. PRESENTATION OF CASE The authors describe two patients with very large anterior trunk dermatofibrosarcoma protuberans: one in the epigastric re...

With Grids, we are able to share computing resources and to provide for scientific communities a global transparent access to local facilities. In such an environment the problems of fair resource sharing and best usage arise. In this paper, the analysis of the LPC cluster usage (Laboratoire de Physique Corpusculaire, CNRS-IN2P3, Clermont-Ferrand, France) in the EGEE Grid environment is done, a...

INSERM U766, Facultés de Médecine et de Pharmacie, Clermont-Ferrand, France (LD ; CM ; CC ; ME ; ED ; AMP ; AE ; JF) ; Université d’Auvergne Clermont 1, Faculté de Pharmacie, Laboratoire de Pharmacologie, Clermont-Ferrand, France (LD ; CC ; ED ; AMP ; JF) ; Université d’Auvergne Clermont 1, Faculté de Médecine, Laboratoire de Pharmacologie Médicale, Clermont-Ferrand, France (CM ; ME ; AE) Molec...

Dermatofibrosarcoma protuberans (DFSP) is a soft tissue tumor with tendency to recur locally and only rarely metastasizes to vital organs. Surgery with wide margins remains the standard treatment. DFSP is characterized by specific chromosomal abnormalities involving the platelet derived growth factor B locus (PDGFB). In the majority of cases a supernumerary ring chromosome containing amplified ...

Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous neoplasm associated with a high cure rate. We present a case of aggressive DFSP with fibrosarcomatous areas in the head and neck. A 28-year-old Mediterranean female presented with a 45-day history of rapidly growing cutaneous lesion of the face. Surgical biopsy confirmed the diagnosis of DFSP. Subsequently, the patient underwent wide lo...