During human ageing, skin becomes thinner and accumulates various skin lesions and imperfections. The structural proteins are progressively damaged causing collagen and elastin lose their resiliency. The skin’s water-holding proteins and sugars diminish, the dermis and epidermis thin, the microcirculation becomes disorganized, and the subcutaneous fat cells diminish in number. Decades of exposu...

OBJECTIVE Split skin graft reconstruction of scalp defects often leaves an obvious contour defect. Here, we aimed to demonstrate the use of a decellularized extracellular matrix biomaterial, termed ovine forestomach matrix (OFM), as a substrate for split-thickness skin grafts (STSGs) for scalp reconstruction. METHODS Following full-thickness tumor excision, OFM was applied directly to skull p...

BACKGROUND One of the main reasons why the breast fat grafting was questioned is that there may be lipofilling resorption. In the literature, the resorption rate reported over the 1(st) year is highly variable (20-90%). OBJECTIVE The aim of this work was to identify the biochemical and clinical parameters, which increase fat graft maintenance in breast reconstruction. MATERIALS AND METHODS ...

Fibrosis is the pathological accumulation of extracellular matrix and can occur in all soft tissues. In many organs, including skin, fibrosis also associated with a loss fat or lipid-filled cells. dermal adipose tissue has critical roles which are likely impacted by fibrotic remodeling. Despite identifying numerous dysregulated signaling pathways common to disease, mechanism remains poorly unde...

Background: Penile foreskin is a readily available source of dermis, but it is not often used for skin grafting. Objective: To report the use of the preputial foreskin as donor for full thickness skin grafting. Methods: The preputial foreskin was used as donor for skin grafting in 42 Thai boys. Results: The size of the donor graft obtained varied from 15-50 cm2 depending on the patients’s weigh...

OBJECTIVE To report on the clinical benefits of platelet gel application in a non-regenerating skin wound. CLINICAL PRESENTATION AND INTERVENTION An 84-year-old man presented with a severe wound with a regular circumference in the frontal region which resulted in a complete loss of epidermis and dermis. The skin lesion, induced by cryosurgery used to remove a basal-cell carcinoma, had previou...

Giant congenital melanocytic nevi (GCMN) are defined as rare pigmented lesions that are believed to form between weeks 9 and 20 of gestation. It is difficult to reconstruct large defects after the removal of the lesions and it has posed a great challenge to the plastic surgeon and dermatologist.Given all those difficulty reconstructing the defects, we try to explore an alternative way to resurf...

BACKGROUND Enucleation in young children often results in retarded orbital growth ipsilaterally. The need for an implant that will naturally grow with the child, like Dermis-fat Graft (DFG), for managing the anophthalmia has been of interest over the years. OBJECTIVE To evaluate the use of DFG as an implant for volume replacement post-enucleation. STUDY DESIGN A prospective non-comparative ...

Neurosurgical Division of the Hospital Geral Santa Isabel, João Pessoa PB, Brazil;Associated Physician. The true importance of performing a watertight dural closure, for neurological procedures, is to avoid several complications such as cerebrospinal fluid (CSF) leakage, pseudomeningocele (PSM), meningitis, cerebral abscess, tonsilar herniation, hydrocephalus, etc. A variety of materials has be...