Abnormal neurodevelopment and poor premorbid function have been described in schizophrenia. It is unclear whether abnormalities in these domains are increased in patients with early onset schizophrenia (EOS; onset before the 18th birthday) and whether they act to precipitate the earlier onset of the disorder. To address these questions, we collected information based on maternal interviews abou...

We used population sample data from 25 societies to answer the following questions: (a) How consistently across societies do adolescents report more problems than their parents report about them? (b) Do levels of parent-adolescent agreement vary among societies for different kinds of problems? (c) How well do parents and adolescents in different societies agree on problem item ratings? (d) How ...

Auditory language comprehension involves physical as well as syntactic processing. The present study examined whether early physical and syntactic processes in spoken sentence comprehension can be segregated using event-related brain potentials (ERPs). In the physical manipulation condition, the terminal word of the sentence was presented either from the same or from a different location to the...

The positive deviance approach assumes that a community’s problems have already been solved. ‘Positive deviants’ succeed despite sharing many of the same constraints as others. Positive deviance, which has its roots in international public health, is increasingly being applied to healthcare, with various-stage process proposed depending on setting. However, quality current healthcare applicatio...

OBJECTIVES By measuring event-related brain potentials (ERPs), the authors tested the sensitivity of the newborn auditory cortex to sound lateralization and to the most common cues of horizontal sound localization. DESIGN Sixty-eight healthy full-term newborn infants were presented with auditory oddball sequences composed of frequent and rare noise segments in four experimental conditions. Th...

The observation that we note the exceptional over the mundane has been the subject of extensive psychological and electrophysiological analysis in "oddball" paradigms. Whether detection of a sensory oddball reflects the operation of a generic mechanism or, alternatively, mechanisms sensitive to specific attributes of stimulus deviance is unknown. To address this question we used event-related f...

Aitkin recently proposed an integrated Bayesian/likelihood approach that he claims is general and simple. We have applied this method, which does not rely on informative prior probabilities or large-sample results, to investigate the evidence of association between disease and the 16 variants in the KDR gene provided by Genetic Analysis Workshop 17. Based on the likelihood of logistic regressio...