L( + )-Arginine hydrochloride was obtained from the Sigma Chemical Co., St Louis, Mo., U.S.A. The Arlco jackbean meal used in the preparation of urease was supplied by Hopkin and Williams Ltd., Chadwell Heath, Essex. The 'manganese-maleate solution' used in the preparation of arginase was made by dissolving 8-9 g. of MnSO4,4H20 and 1-8 g. of disodium maleate in glassdistilled water and making t...

Buccal bioadhesive bilayer tablets of prochlorperazine maleate were designed and formulated by using buccoadhesive polymers such as hydroxypropylmethyl cellulose, Carbopol 934P, and sodium alginate. Physicochemical characteristics like the uniformity of weight, hardness, thickness, surface pH, drug content, swelling index, microenvironment pH, in vitro drug release, and in vivo buccoadhesion ti...

We describe a 66-year-old man who developed bilateral choroidal detachment that was induced by unilateral topical administration of a fixed combination of 1% brinzolamide and 0.5% timolol maleate the day after an uneventful phacoemulsification surgery and intraocular lens implantation involving his right eye. We believe that the reaction was an idiosyncratic reaction, most likely against brinzo...

The aim of the present study was to formulate polymer microspheres using emulsion solvent evaporation technique as an approach mask bitter taste enalapril maleate. Five models were prepared with two water-insoluble polymers. Talc used stabilize particle structure. Production yields ranged from 38 % 53 %; drug loading varied between 17 and 40 mean size 140 μm 339 μm. No interaction polymers esti...

Enalapril maleate, the oldest and most widely distributed ACEI, and alacepril, the newest and antioxidant ACEI, were compared in the point of cardioprotective effect for Dahl salt-sensitive rat. In order to evaluate the correlation between the three factors, cardiac fibrosis and blood pressure/oxidative-stress marker (tissue TBARS), index of correlation was calculated. The results showed a sign...