In the title compound, C20H16N2O2, the condensed tricyclic fragment is near to planar, with an r.m.s. deviation of 0.0531 Å. The 1,4-di-hydro-pyridine (1,4-DHP) ring adopts a slightly puckered boat-like conformation. The N and opposite C atoms deviate from the least-squares plane of the four other ring atoms by 0.039 (3) and 0.141 (3) Å, respectively. The C=O group located at the tricyclic frag...

The leaf area index (LAI) of three monocultures of Norway spruce (Picea abies (L.) Karst), different in age and structure, was measured by means of two indirect optical techniques of LAI field mapping: 1/ plant canopy analyser LAI-2000, and 2/ digital hemispherical photographs (DHP). The supportive measurements with the TRAC instrument were conducted to produce mainly the element clumping index...

Dihydropyridines (DHPs) generally have little effect on whole-cell calcium currents of neurons, even at concentrations far higher than those effective on muscle. Either neuronal calcium currents are much less sensitive to DHPs, or only a small proportion of the current is DHP-sensitive. We find that DHP agonists and antagonists act at low concentration on calcium currents in frog sympathetic ne...

Abnormal accumulation of amyloid beta peptide (Aβ) is one of the hallmarks of Alzheimer's disease progression. Practical limitations such as cost , poor hit rates and a lack of well characterized targets are a major bottle neck in the in vitro screening of a large number of chemical libraries and profiling them to identify Aβ inhibitors. We used a limited set of 1,4 dihydropyridine (DHP)-like c...

The genes within the dihydropyrimidinase-related protein (DRP) family, were originally identified in humans by their homology to dihydropyrimidinase (DHP). Four members of this gene family, DRP-1, -2, -3 and -4, are expressed mainly in the fetal and neonatal brains of mammals and chickens, and have been implicated as intracellular signal transducers in the development of the nervous system. We ...

Introduction. The toxic nonprotein amino acid mimosine present in Leucaena leucocephala is degraded by rumen bacteria to produce another toxic compound, 3-hydroxy-4(lH)-pyridone (3,4-dihydroxypyridine, or 3,4-DHP). In some, but not all, geographic areas ruminants are colonized by bacteria that degrade 3,4-DHP, and actions of these microbes protect their host animals from leucaena toxicosis (Jon...

We reconstruct the vertical pulse power distribution returned from a commercial small footprint discrete pulse airborne laser terrain mapper within a mixed forest landscape. By modifying a Beer-Lambert approach, we relate the ratio of ground return power / total return power to the canopy gap fraction (P) as derived from digital hemispherical photography (DHP). The results are compared to the c...

Some novel Schiff bases derived from 1-(2-ketoiminoethyl)piperazines were synthesized and characterized by mass spectroscopy, FTIR, UV-Visible, 1H and 13C-NMR. The compounds were tested for inhibitory activities on human acetylcholinesterase (hAChE), antioxidant activities, acute oral toxicity and further studied by molecular modeling techniques. The study identified the compound (DHP) to have ...

In order to determine the most effective hormones on the in vitro oocyte maturation (germinal vesicle breakdown GVBD) in a hybrid sturgeon bester, ovarian follicles were incubated at the migratory nucleus stage in the presence of several steroids, gonadotropin preparations and forskolin. Occurrence of GVBD and 17,20β-dihydroxy-4-pregnen-3 -one (DHP) production were followed during an experiment...

Nucleic acids have become a powerful tool in nanotechnology because of their conformational polymorphism. However, lack of a medium in which nucleic acid structures exhibit long-term stability has been a bottleneck. Ionic liquids (ILs) are potential solvents in the nanotechnology field. Hydrated ILs, such as choline dihydrogen phosphate (choline dhp) and deep eutectic solvent (DES) prepared fro...