A 34-year-old woman with type 1 diabetes on hemodialysis was admitted to our hospital for simultaneous pancreas kidney transplantation received from her father. She had suffered from type 1 diabetes mellitus since age 13, and had complained of serious atonic gastroenteropathy and orthostatic hypotension. After the transplantation, she became free from hemodialysis and insulin injection. At the ...

Purpose of review Wolfram syndrome 1 (WS1) is an autosomal recessive disorder characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness (DI DM OA D syndrome) associated with other variable clinical manifestations. The causative gene for WS1 (WFS1) encoding wolframin maps to chromosome 4p16.1. Wolframin has an important function in maintaining the homeostasis of the end...

Wolfram syndrome is the condition characterized by juvenile onset diabetes mellitus and optic atrophy, which also known as DIDMOAD. Classical a rare autosomal recessive disorder caused mutations in WFS1, gene involved endoplasmic reticulum mitochondrial function. Patients present with type 1 followed atrophy first decade, insipidus sensorineural deafness second dilated renal outflow tracts earl...

INTRODUCTION Pituitary adenomas represent the most frequently observed type of sellar masses; however, the presence of a rapidly growing sellar tumor, diabetes insipidus, ophthalmoplegia and headaches in an older patient strongly suggests metastasis to the pituitary. Since the anterior pituitary has a great reserve capacity, metastasis to the pituitary and pituitary involvement in lymphoma are ...

We report a rare case of diabetes insipidus following fire burn injury. Meticulous fluid balance and the use of carbamazepine resulted in her survival.

SUMMARY A 71 - year old woman with symptomatic Rathke's Cleft cyst is reported. She had Visual disturbance, diabetes insipidus and hypopituitarism. Imaging study with computed tomography revealed the presence of suprasellar mass. After the transsphenoidal surgery and treatment with DDA VP, her symptoms showed an improvement.

Craniopharyngioma is an embryonic malformation in the sella and parasella areas. has high survival rate, although patient's quality of life often compromised due to tumor’s location near important anatomical structures such as optic nerve, chiasm, hypothalamic-pituitary axis. tumor resection can provoke diabetes insipidus. Diabetes insipidus (DI) characterized by polyuria, dehydration hypernatr...