Background: Diabetes mellitus is an endocrine disorder of carbohydrate metabolism resulting primarily from inadequate insulin release (type I) or insulin insensitivity coupled with inadequate compensatory insulin release (type II). Oxidative stress is one of the complications of diabetes that increases in both types of diabetes and treatment with antioxidants can reduce the complications of dia...

Studies from the last decade emphasize the importance of sialic acid (SA) in general pathology (neoplasic disease, colagenosis), and its implication in appearance and aggravation of atherosclerosis (e.g. appearance of angyopathy like chronic complication in diabetes mellitus). Diabetes is known as a major risk factor for atherosclerosis and has a high incidence in general population. The incide...

BACKGROUND In this study we have investigated the effects of type I (insulin-dependent) and II (non-insulin dependent) diabetes mellitus on the specific activity and the output of salivary exoglycosidases: N-acetyl-β-hexosoaminidase (HEX), and its isoenzymes A and B (HEX A, HEX B), and β-glucuronidase (GLU) in well controlled diabetic patients compared to healthy age-matched controls. MATERIA...

Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia. The management of the blood glucose level is a critical strategy in the control of diabetes complications. Inhibitors of carbohydrate hydrolyzing enzymes have been useful as oral hypoglycemic drugs for the control of hyperglycemia especially in patients with type II disables mellitus. The goal of the present study...