Background—Heart failure is a common cause of morbidity and mortality in diabetic patients that frequently manifests in the absence of impaired left ventricular systolic function. In contrast to the strong evidence base for the treatment of systolic heart failure, the treatment of heart failure with preserved left ventricular function is uncertain, and therapeutic targets beyond blockade of the...

Mitochondrial dysfunction is a contributor to diabetic cardiomyopathy. Previously, we observed proteomic decrements within the inner mitochondrial membrane (IMM) and matrix of diabetic cardiac interfibrillar mitochondria (IFM) correlating with dysfunctional mitochondrial protein import. The goal of this study was to determine whether overexpression of mitochondria phospholipid hydroperoxide glu...

Diabetes mellitus was induced in female Wistar rats by injections of either alloxan or streptozotocin, and their embryos were found to have significantly higher incidences (7.5%) of brain and heart abnormalities (non-closure of neural folds, and deformities of heart chambers) at mid-gestation than controls (2.2%). There were also increased numbers of resorptions (25% in diabetic animals: 7.2% i...

BMJ 1993;306:493 Cardiovascular disease is three times more common in diabetic patients than the non-diabetic population and is the main cause of death in people with non-insulin dependent diabetes mellitus.' The importance of the plasma triglyceride concentration as a risk factor for coronary heart disease in the general population is still uncertain. In diabetic patients, however, triglycerid...

The present study was designed to examine the effects of lead nitrate (LN) and whether selenium has a cardioprotective effect on diabetic and non-diabetic rats. Selenium and LN were administered orally for 28 days to streptozotocin-induced diabetic and non-diabetic rats. Animals were divided into 8 groups: control, sodium selenite, LN, LN+Sodium selenite, diabetic-control, diabetic sodium selen...

BACKGROUND Overexpression of lectin-like low density lipoprotein (LOX-1) receptor plays an important role in hyperglycemia-induced vascular complications such as atherosclerosis. Based on the beneficial effects of exercise on preventing cardiovascular complications of diabetes, we aimed to examine the protective effects of aerobic exercise on expression of LOX-1 receptor and production of free ...

To examine the role of changes in myocardial metabolism in cardiac dysfunction in diabetes mellitus, rats were injected with streptozotocin (65 mg/kg body wt) to induce diabetes and were treated 2 wk later with the carnitine palmitoyltransferase inhibitor (carnitine palmitoyltransferase I) etomoxir (8 mg/kg body wt) for 4 wk. Untreated diabetic rats exhibited a reduction in heart rate, left ven...

Background: The potential role of exercise in physiological cardiac hypertrophy is rooted both hormonal and genetic components. Objectives: aim this study was to determine the impact resistance on expression PI3K AKT1 tissue type 2 diabetes (T2D) rats their hypertrophy. Methods: First, 21 male Wistar (220±20 g) were obese with 6-week high-fat diet (HFD) randomly assigned into non-diabetes, cont...

OBJECTIVES To study the prognosis and cause of death in cats with diabetes mellitus. METHODS Twenty consecutive cases of feline diabetes mellitus diagnosed in first-opinion practice were followed. Three control cats, without diabetes, were matched to each case of diabetes; these were also followed. RESULTS One Somali cat with diabetes could not be matched, so complete data analysis consider...