OBJECTIVE Diabetic retinopathy is a sight-threatening microvascular complication of diabetes with a complex multifactorial pathogenesis. A systematic meta-analysis was undertaken to collectively assess genetic studies and determine which previously investigated polymorphisms are associated with diabetic retinopathy. RESEARCH DESIGN AND METHODS All studies investigating the association of gene...

BACKGROUND Increasing the level of awareness of diabetic retinopathy among individuals with type 2 diabetes mellitus is considered an important factor for early diagnosis and management of diabetic retinopathy. The aim of this study was to evaluate awareness of diabetic retinopathy among a sample of type 2 diabetes mellitus patients in Jordan. PATIENTS AND METHODS The study period was from Au...

BACKGROUND The Steno hypothesis states that changes in basement membrane anionic charge leads to diabetic microvascular complications. In diabetic nephropathy, loss of basement membrane glycosaminoglycans and the association between glomerular basement membrane heparan sulphate and proteinuria has been documented. A correlation between erythrocyte surface and the glomerular capillary wall charg...

BACKGROUND Sub-Saharan Africa faces an epidemic of diabetes. Diabetes causes significant morbidity including visual loss from diabetic retinopathy, which is largely preventable. In this resource-poor setting, health systems are poorly organized to deliver chronic care with multiple system involvement. The specific skills and resources needed to manage diabetic retinopathy are scarce. The costs ...

Diabetic retinopathy is emerging as one of the important causes of blindness in both developing and developed countries. High hemoglobin A1c level, high 2-hr blood glucose level, low uric acid level and positivity for proteinuria were found to be significantly associated for the development diabetic retinopathy. The study was done on a total of 75 subjects. They were divided into 3 groups as: G...

OBJECTIVE To evaluate the validity and reproducibility of software for reading digital images and grading diabetic retinopathy. RESEARCH DESIGN AND METHODS A prospective, comparative observational study was conducted on a series of patients with type 2 diabetes who presented at the retina clinic of a tertiary care center in India. A total of 210 eyes of 105 patients were allocated to one of t...

Diabetic patients with and without complications show a difference in serum uric acid pattern in relation to duration of disease along with glycemic status, lipid derangements and complications associated with the disease. HbA1c studies were taken to know the blood sugar levels for the past 3 months to assess the glycemic control. Study of lipid profile is also taken to assess the micro vascula...

PURPOSE To evaluate the prevalence of diabetic retinopathy and risk factors among patients with self-reported diabetes mellitus in China. METHODS The Beijing Eye Study, a population-based study on inhabitants aged 40+ years, included 4439 subjects. Fundus photographs of the worse eye from participants with self-reported diabetes were graded. RESULTS Fundus photographs ready for evaluation a...

BACKGROUND The aim of this study was assessment of predictive factors of diabetic retinopathy. METHODS A cross-sectional study was designed by recruiting 1228 type 2 diabetic patients from a diabetes referral clinic over a six-month period (from July to December, 2012). Diabetes risk factors, complications, laboratory results have been recorded. RESULTS Of the 1228 diabetic patients (54% wo...

BACKGROUND Retinopathy is one of the most frequent and serious complication of diabetes mellitus and leading cause of blindness worldwide. The objective of this study was to determine frequency and pattern of retinopathy in newly diagnosed type 2 diabetic patients at tertiary care settings in Abbottabad. METHODS This was a descriptive cross-sectional comparative study being conducted at Ayub ...