introduction: it is generally accepted that breast feeding has a beneficial effect on the health of infants and children. the evidence that breast feeding protects against obesity is inconclusive also the influence of breast feeding on blood pressure in later life is uncertain. the major aim of this study was to assess the association between method of infant breast feeding and components of th...

Cerebral white matter hyperintensities on brain MRI (leukoaraiosis) are associated with increased risk of stroke and dementia. To assess the relationships of blood pressure level and circadian pattern with leukoaraiosis, we obtained 24-hour ambulatory blood pressure recordings and brain magnetic resonance images in 343 white and 267 black adults who were members of sibships that had >or=2 sibli...

BACKGROUND In patients with type 2 diabetes, the prognostic impact of an orthostatic rise in blood pressure is not known. Therefore, the aim of this study was to determine the prognostic implications of the diastolic orthostatic blood pressure response in a cohort of patients with type 2 diabetes. We also evaluated associations between different orthostatic blood pressure responses and markers ...

Previously we demonstrated that pulse pressure is a strong risk factor for coronary events in male hypertensive subjects in the MRC Mild Hypertension Trial, whereas stroke is best predicted by mean blood pressure. In this study, we have assessed the implications of this finding in the treatment of mild essential hypertension. We examined the relationship between diastolic blood pressure and bot...

BACKGROUND The optimum blood pressure target in hypertension remains debated, especially in coronary artery disease, given concerns for reduced myocardial perfusion if diastolic blood pressure is too low. We aimed to study the association between achieved blood pressure and cardiovascular outcomes in patients with coronary artery disease and hypertension. METHODS We analysed data from 22 672 ...

Cardiovascular reactivity to stress may have a pathophysiological role in neurogenic hypertension. We studied the value of measuring blood pressure change during standardized mental and physical challenges to prediction of resting blood pressure status 6.5 years later among 206 middle-aged adults and their 164 children, with the latter group originally being tested while enrolled in elementary ...

Experiments are presented to show the effects of (1) propranolol on tbe response of systolic blood pressure and diastolic blood pressure to bilateral carotid artery occlusion in choralose-anesthetized dogs; (2) the effects of propranolol on acute hypertensive states in chloralose-anesthetized dogs; and (3) the effects of propranolol on the response of trained awake dogs to bilateral carotid art...

OBJECTIVE To investigate the relation between mortality and treated systolic and diastolic blood pressures. DESIGN Randomised double blind placebo controlled trial. Mortality in the two treatment groups was examined in thirds of treated systolic and diastolic blood pressures. PATIENTS 339 And 352 patients allocated to placebo and active treatment, respectively. The groups were similar at ra...