EEG effects of zopiclone (7.5 mg), a cyclopyrrolone derivative with hypnotic action, were compared with effects of diazepam (10 mg). Multichannel EEG recordings, double-blind crossover trials with placebo, and oral single doses were used in healthy volunteers. Vigilance-controlled EEG before and after zopiclone (and placebo), and before and after diazepam (and placebo) were analyzed into FFT po...

We evaluated whether tolerance to the antagonism of bicuculine-induced seizures by diazepam is associated with changes (i) in the content of mRNAs encoding for gamma-aminobutyric acidA (GABAA) receptor subunits, (ii) in the expression density of these subunits, and (iii) in the 1,4-benzodiazepine binding site characteristics in discrete neocortical structures. We found that in diazepam-tolerant...

relieving withdrawal and post-abstinence syndrome of alcoholism is one of the major strategies in the treatment of alcohol addicted patients. diazepam, chlordiazepoxide, and topiramate are the approved medications that were used for this object. to assess the role of non-pharmacologic therapy in the management of alcohol withdrawal syndrome, we analyzed effects of forced exercise by treadmill o...

This study aimed to determine the anesthetic efficacy of intranasal medetomidine/ketamine and diazepam/ketamine combinations in New Zealand White rabbits. For this purpose, 12 adult rabbits weighing 2.3‐4.1 kg were used by randomly dividing animals into two groups six animals: Medetomidine ‐ Ketamine (MK) Diazepam (DK). Intranasally, medetomidine (0.2 mg kg‐1) ketamine (10 combination was admin...

In order to compare rectal and intravenous(IV) administration of diazepam for management of convulsions,a prospective cross-sectional case-control study was conducted on 94 convulsive infants and children referring to the Emergency department of the university hospital No.1 in Kerman.all children were randomly divided into two groups.the patients were matched with regard to the cause,type,durat...

Anxiety disorders are more prevalent not only in normal individuals but also in diabetes mellitus. Diazepam, a benzodiazepine, and buspirone, an azaspirodecanedione, are the most often prescribed anxiolytics. Present study was aimed to investigate the effect of diazepam and buspirone on the blood sugar levels in rabbits. Buspirone (0.5 mg/kg/day p.o.) and diazepam (0.6 mg/kg/day p.o.) did not a...

Diazepam and chlorpromazine - psychotropic agents widely used for the amelioration of anxiety, depression, and psychosis, have been found to affect cell proliferation. We have checked whether these drugs influence proliferation of endothelial cells and probably angiogenesis process. We have studied the effect of diazepam and chlorpromazine on proliferative activity and vascular endothelial grow...

Pharmaceutical availability of diazepam, oxazepam and nitrazepam from solid dispersions of PVP have been studied in comparison to those of the corresponding physical mixtures and pure benzodiazepines. The derivatives of 1,4-benzodiazepin-2-one are poorly water soluble drugs. The properties of diazepam-, oxazepam- and nitrazepam-PVP solid dispersions have been determined by the methods of differ...

Diazepam, an antianxietic agent, antagonized the stress-induced analgesia (SIA) distinctively depending on the characteristics of the stress. Psychological (PSY, using communication box)-SIA was completely blocked by 1 or 2 mg/kg of diazepam in the tail pinch (TP) method, but not antagonized by 1 mg/kg of the drug in the tail flick test. Swimming-SIA was resistant to diazepam in both methods an...

Droperidol 5 mg and 10 mg and diazepam 10 mg were compared in premedication studies with morphine 10 mg and saline. Droperidol caused less hypnosis than either morphine or diazepam, and its use was associated with a much higher incidence of anxiety among patients than was observed in the group who had received saline only. Dizziness and restlessness were also significant features of the action ...