background: infertility is a health problem which affects about 10-20% of married couples. male factor infertility is involved approximately 50% of infertile couples. most of male infertility is regarding to deletions in the male-specific region of the y chromosome. objective: in this study, the occurrence of deletions in the azf region and association between infertility and paternal age were ...

Yeast strains with mutations in both TEL1 and MEC1 have short telomeres and elevated rates of chromosome deletions. By using a PCR assay, we demonstrate that mec1 tel1 strains also have telomere-telomere fusions (T-TFs). T-TFs require Lig4p (a ligase required for nonhomologous end-joining DNA repair). The highest rates of T-TFs are found in strains with combination of mutations that affect telo...

Replication fork inactivation can be overcome by homologous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregate at mitosis, driving further chromosome instability. It is unclear when the chromosome rearrangements are generated and whether individual replication problems or the resulting recombination intermediates delay the cell cycle. Here we have ...

The centromere is a specialized chromosomal region identified as the major constriction, upon which the kinetochore complex is formed, ensuring accurate chromosome orientation and segregation during cell division. The rapid evolution of centromere DNA sequence and the conserved centromere function are two contradictory aspects of centromere biology. Indeed, the sole presence of genetic sequence...

1. Kobayashi H, Montgomery KT, Bohlander SK, Adra CN, Lim BL, Kucherlapati RL, Donis-Keller H, Holt MS, Le Beau MM, Rowley JD: Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases. Blood 84:3473, 1994 2. Golub TR, Baker GF, Lovett M, Gilliland DG: Fusion of PDGF receptor b to a novel ets-like ...

constitution was undertaken. L1210/Mes. has a tetraploid modal chromosome number, the chromosomes of which resemble, although in increased quantity, those of the original LI210 lymphoma of the mouse. However, a new marker chromosome, a long, biarmed dicentric, appeared in 8.6% of the L1210/Mes. cells examined. L1210/Mes. is capable of back-transfer in BDP! mice, where a gradual shift in stemlin...